7-(3-azetidinyl)-5-(1-[(3-methyl phenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Base Information

Chemical Name:7-(3-azetidinyl)-5-(1-[(3-methyl phenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS No.:1337531-85-7
Molecular Formula:C₂₆H₂₆N₆O
Molecular Weight:438.532
Hs Code.:

Synonyms:7-(3-azetidinyl)-5-(1-[(3-methyl phenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Chemical Property of 7-(3-azetidinyl)-5-(1-[(3-methyl phenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Technology Process of 7-(3-azetidinyl)-5-(1-[(3-methyl phenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

There total 6 articles about 7-(3-azetidinyl)-5-(1-[(3-methyl phenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1337533-12-6
1,1-dimethylethyl 3-(4-amino-5-(1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate

: 1337531-85-7
7-(3-azetidinyl)-5-(1-[(3-methyl phenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: With hydrogenchloride; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; at 50 ℃; for 1h;

Reference yield:

: 22276-95-5
5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 1337531-85-7
7-(3-azetidinyl)-5-(1-[(3-methyl phenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 20 - 60 °C

2: ammonium hydroxide / 2 h / 100 °C / Microwave irradiation

3: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 120 °C / Microwave irradiation

4: hydrogenchloride; trifluoroacetic acid / dichloromethane; 1,4-dioxane; water / 1 h / 50 °C

With hydrogenchloride; ammonium hydroxide; sodium hydrogencarbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1337531-85-7
7-(3-azetidinyl)-5-(1-[(3-methyl phenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / chloroform / 3 h / 20 - 70 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 20 - 60 °C

3: ammonium hydroxide / 2 h / 100 °C / Microwave irradiation

4: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 120 °C / Microwave irradiation

5: hydrogenchloride; trifluoroacetic acid / dichloromethane; 1,4-dioxane; water / 1 h / 50 °C

With hydrogenchloride; ammonium hydroxide; N-Bromosuccinimide; sodium hydrogencarbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water;