Technology Process of 4-(4-hydroxyphenyl)furoxan-3-carbonitrile
There total 15 articles about 4-(4-hydroxyphenyl)furoxan-3-carbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanesulfonic acid; L-methionine;
at 60 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: diisobutylaluminium hydride / dichloromethane / 1 h / -70 - 20 °C
2: sodium nitrite; acetic acid / water / 20 °C
3: Dess-Martin periodane / dichloromethane / 20 °C
4: hydroxylamine hydrochloride; pyridine / ethanol / 3 h / 95 °C / Reflux
5: thionyl chloride / N,N-dimethyl-formamide / 20 °C
6: L-methionine; methanesulfonic acid / 3 h / 60 °C
With
pyridine; thionyl chloride; methanesulfonic acid; L-methionine; hydroxylamine hydrochloride; diisobutylaluminium hydride; Dess-Martin periodane; acetic acid; sodium nitrite;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 83 percent / AlCl3 / CH2Cl2 / 24 h / 60 °C
2: 78 percent / triethylamine / diethyl ether / 1 h / -15 °C
3: MnO2 / CH2Cl2 / 12 h
4: hydroxylamine hydrochloride; pyridine / acetonitrile / 1 h / 60 °C
5: NaOH / H2O / 0.17 h / 0 °C
6: 4.62 g / SOCl2 / dimethylformamide / 0.5 h
With
pyridine; manganese(IV) oxide; sodium hydroxide; aluminium trichloride; thionyl chloride; hydroxylamine hydrochloride; triethylamine;
In
diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2005.05.004
