4-(2-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-((4-methoxybenzyloxy)methyl)butan-1-ol

Base Information

• Chemical Name: 4-(2-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-((4-methoxybenzyloxy)methyl)butan-1-ol
• CAS No.: 888324-97-8
• Molecular Formula: C₂₆H₄₀O₄Si
• Molecular Weight: 444.687
• Mol file: 888324-97-8.mol

Synonyms:4-(2-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-((4-methoxybenzyloxy)methyl)butan-1-ol

Chemical Property of 4-(2-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-((4-methoxybenzyloxy)methyl)butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-((4-methoxybenzyloxy)methyl)butan-1-ol

There total 9 articles about 4-(2-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-((4-methoxybenzyloxy)methyl)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-(2-((tert-butyldimethylsilyloxy)methyl)phenethyl)propane-1,3-diol (888324-96-7) + p-methoxybenzyl chloride (824-94-2) → 4-(2-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-((4-methoxybenzyloxy)methyl)butan-1-ol (888324-97-8)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 0 - 20 ℃;

DOI:10.1021/ol0604264

Reference yield:

2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethanol (888324-77-4) → 4-(2-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-((4-methoxybenzyloxy)methyl)butan-1-ol (888324-97-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 93 percent / LiBr; Et₃N; methanesulfonyl chloride / tetrahydrofuran / 144 h / 20 °C

2.1: NaH / tetrahydrofuran / 20 °C

2.2: 80 percent / NaI / acetonitrile / 12 h / 60 °C

3.1: 93 percent / LiAlH₄ / diethyl ether / 5 h / 0 - 20 °C

4.1: 58 percent / NaH; tetrabutylamminium iodide / tetrahydrofuran; dimethylsulfoxide / 0 - 20 °C

With lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; sodium hydride; methanesulfonyl chloride; triethylamine; lithium bromide; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;

DOI:10.1021/ol0604264

Reference yield:

[2-(2-bromo-ethyl)-benzyloxy]-tert-butyl-dimethyl-silane (951776-91-3) → 4-(2-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-((4-methoxybenzyloxy)methyl)butan-1-ol (888324-97-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 20 °C

1.2: 80 percent / NaI / acetonitrile / 12 h / 60 °C

2.1: 93 percent / LiAlH₄ / diethyl ether / 5 h / 0 - 20 °C

3.1: 58 percent / NaH; tetrabutylamminium iodide / tetrahydrofuran; dimethylsulfoxide / 0 - 20 °C

With lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;

DOI:10.1021/ol0604264

upstream raw materials:

2-(2-((tert-butyldimethylsilyloxy)methyl)phenethyl)propane-1,3-diol

p-methoxybenzyl chloride

2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethanol

[2-(2-bromo-ethyl)-benzyloxy]-tert-butyl-dimethyl-silane

Downstream raw materials:

6-(2-((tert-butyldimethylsilyloxy)methyl)phenyl)-4-((4-methoxybenzyloxy)methyl)-2-(tert-butyldimethylsilyloxy)hex-1-en

6-(2-((tert-butyldimethylsilyloxy)methyl)phenyl)-4-((4-methoxybenzyloxy)methyl)hex-1-en-3-ol

3-(tert-butyldimethylsilyloxy)-2-{2-[2-(tert-butyldimethylsilyloxymethyl)phenyl]ethyl}pent-4-en-1-ol

Se-phenyl 2-[4-(tert-butyldimethylsilyloxy)-3-vinylhex-5-enyl]benzoselenoate