Technology Process of (R)-3-[5-methyl-2-((E)-2-(4-methylphenyl)ethenyl)phenyl]cyclohexanone
There total 6 articles about (R)-3-[5-methyl-2-((E)-2-(4-methylphenyl)ethenyl)phenyl]cyclohexanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
C50H68Cl2O4Rh2; caesium carbonate;
In
1,4-dioxane; water;
at 70 ℃;
for 4h;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1016/j.tetasy.2012.03.004
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 3 h / -78 - -40 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: hydrogenchloride; water / tetrahydrofuran; pentane / 1 h / 20 °C
3.1: C50H68Cl2O4Rh2; caesium carbonate / 1,4-dioxane; water / 4 h / 70 °C
With
hydrogenchloride; C50H68Cl2O4Rh2; water; tert.-butyl lithium; caesium carbonate;
In
tetrahydrofuran; 1,4-dioxane; water; pentane;
DOI:10.1016/j.tetasy.2012.03.004
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride; water / tetrahydrofuran; pentane / 1 h / 20 °C
2: C50H68Cl2O4Rh2; caesium carbonate / 1,4-dioxane; water / 4 h / 70 °C
With
hydrogenchloride; C50H68Cl2O4Rh2; water; caesium carbonate;
In
tetrahydrofuran; 1,4-dioxane; water; pentane;
DOI:10.1016/j.tetasy.2012.03.004
