(3-Amino-2,6-difluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone

Base Information

• Chemical Name: (3-Amino-2,6-difluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone
• CAS No.: 1312941-98-2
• Molecular Formula: C₁₄H₈BrF₂N₃O
• Molecular Weight: 352.138
• Mol file: 1312941-98-2.mol

Synonyms:(3-amino-2,6-difluorophenyl)-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone

Chemical Property of (3-Amino-2,6-difluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone

Chemical Property:

• PKA: 10.55±0.40(Predicted)
• Density: 1.759±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

(3-Amino-2,6-difluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-Amino-2,6-difluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone

There total 7 articles about (3-Amino-2,6-difluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.65%

(2,6-difluoro-3-nitrophenyl)-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone → (3-amino-2,6-difluorophenyl)-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone (1312941-98-2)

Guidance literature:

With tin(ll) chloride; In 2-methyltetrahydrofuran; at 60 ℃; Large scale;

Reference yield:

[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-carbamic acid methyl ester (918521-11-6) → (3-amino-2,6-difluorophenyl)-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone (1312941-98-2)

Guidance literature:

With trimethylsilyl iodide; In acetonitrile; at 20 ℃; Inert atmosphere;

Reference yield:

2,6-difluoro-3-nitrobenzoic acid chloride (260552-98-5) → (3-amino-2,6-difluorophenyl)-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone (1312941-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / 1,2-dichloro-ethane / 1.5 h / 45 - 50 °C / Large scale

2: tin(ll) chloride / 2-methyltetrahydrofuran / 60 °C / Large scale

With aluminum (III) chloride; tin(ll) chloride; In 2-methyltetrahydrofuran; 1,2-dichloro-ethane;

upstream raw materials:

methyl N-(2,4-difluoro-3-formyl-phenyl)carbamate

{3-[(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-hydroxy-methyl]-2,4-difluoro-phenyl}-carbamic acid methyl ester

[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-carbamic acid methyl ester

2,6-difluoro-3-nitrobenzoic acid chloride

Downstream raw materials:

N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide

N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]propane-1-sulfonamide

propane-1-sulfonic acid {3-[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}amide

5-{3-[3-(2,5-difluoro-benzenesulfonylamino)-2,6-difluoro-benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-indazole-1-carboxylic acid methylamide