1-Propanesulfonamide, N-[3-[[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-

Base Information

• Chemical Name: 1-Propanesulfonamide, N-[3-[[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-
• CAS No.: 1262985-24-9
• Molecular Formula: C24H16BrCl2F2N3O4S
• Molecular Weight: 631.282
• Mol file: 1262985-24-9.mol

Synonyms:N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

Chemical Property of 1-Propanesulfonamide, N-[3-[[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-

Chemical Property:

• PSA: 106.51000
• LogP: 7.60880
• Storage Temp.: 2-8°C

Purity/Quality:

99.9% ^*data from raw suppliers

N-(3-(5-Bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Propanesulfonamide, N-[3-[[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-

There total 10 articles about 1-Propanesulfonamide, N-[3-[[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]propane-1-sulfonamide (918504-27-5) + 2,6-Dichlorobenzoyl chloride (4659-45-4) → propane-1-sulfonic acid {3-[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}amide (1262985-24-9)

Guidance literature:

With tri-n-propylamine; dmap; In toluene; at 20 - 25 ℃;

Reference yield:

5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7) → propane-1-sulfonic acid {3-[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}amide (1262985-24-9)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium hydroxide / methanol / 20 °C / Inert atmosphere

2: Dess-Martin periodane / tetrahydrofuran / 2 h / 20 °C

3: trimethylsilyl iodide / acetonitrile / 20 °C / Inert atmosphere

4: pyridine / dichloromethane / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dmap / toluene / 20 °C / Inert atmosphere

With pyridine; trimethylsilyl iodide; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dmap; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

methyl N-(2,4-difluoro-3-formyl-phenyl)carbamate (1309431-01-3) → propane-1-sulfonic acid {3-[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}amide (1262985-24-9)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium hydroxide / methanol / 20 °C / Inert atmosphere

2: Dess-Martin periodane / tetrahydrofuran / 2 h / 20 °C

3: trimethylsilyl iodide / acetonitrile / 20 °C / Inert atmosphere

4: pyridine / dichloromethane / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dmap / toluene / 20 °C / Inert atmosphere

With pyridine; trimethylsilyl iodide; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dmap; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;

upstream raw materials:

N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]propane-1-sulfonamide

2,6-Dichlorobenzoyl chloride

5-bromo-1H-pyrrolo[2,3-b]pyridine

methyl N-(2,4-difluoro-3-formyl-phenyl)carbamate

Downstream raw materials:

propane-1-sulfonic acid {3-[5-(4-chlorophenyl) 1-(2,6-dichloro-benzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide

propane-1-sulfonic acid {3-[1-(2,6-dichloro-benzoyl)-5-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide

propane-1-sulfonic acid {2,4-difluoro-3-[5-(1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-amide

propane-1-sulfonic acid {3-[5-(1-acetyl-1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide