[5-(4-iodo-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester

Base Information

Chemical Name:[5-(4-iodo-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester
CAS No.:1415654-19-1
Molecular Formula:C₂₃H₂₈INO₅S
Molecular Weight:557.45
Hs Code.:

Synonyms:[5-(4-iodo-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester

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Chemical Property of [5-(4-iodo-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester

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Technology Process of [5-(4-iodo-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester

There total 6 articles about [5-(4-iodo-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1415654-17-9
(5-amino-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy)-acetic acid tert-butyl ester

: 98-61-3
p-Iodobenzenesulfonyl chloride

: 1415654-19-1
[5-(4-iodo-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 14h;

Reference yield:

: 87779-79-1
6-bromobenzocycloheptan-1-one

: 1415654-19-1
[5-(4-iodo-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane; water / 80 °C / Inert atmosphere

2.1: caesium carbonate / acetonitrile / 20 °C / Inert atmosphere

3.1: ammonium acetate / methanol / 20 °C / Inert atmosphere

3.2: 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 14 h / 20 °C

With ammonium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;

Reference yield:

: 826-73-3
1-Benzosuberone

: 1415654-19-1
[5-(4-iodo-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine; aluminum (III) chloride / 80 °C / Inert atmosphere

2.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane; water / 80 °C / Inert atmosphere

3.1: caesium carbonate / acetonitrile / 20 °C / Inert atmosphere

4.1: ammonium acetate / methanol / 20 °C / Inert atmosphere

4.2: 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 14 h / 20 °C

With aluminum (III) chloride; ammonium acetate; bromine; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;