98-61-3

Usage

Chemical Properties

white to beige or orange crystals or

Uses

It is used as intermediate in organic syntheses & in medicine.

General Description

The reaction of 4-iodobenzenesulfonyl chloride (pipsyl chloride) with peptides under various conditions has been studied.

InChI:InChI=1/C6H4ClIO2S/c7-11(9,10)6-3-1-5(8)2-4-6/h1-4H

Upstream product

• 591-50-4 iodobenzene 
• 35371-03-0 4-iodothioanisole 
• 13035-63-7 4-iodobenzenesulfonic acid 
• 87424-99-5 ethyl-(4-iodo-phenyl)-sulfide 
• 121-57-3 4-aminobenzene sulfonic acid 
• 7790-94-5 chlorosulfonic acid 
• 67-66-3 chloroform 
• 7782-50-5 chlorine 
• 5122-99-6 4-iodophenylboronic acid 
• 1514-50-7 4-iodobenzenediazonium tetrafluoroborate 

Downstream Products

• 914930-12-4 4-iodobenzenesulfonic acid methyl ester 
• 68305-79-3 N-(4-iodo-benzenesulfonyl)-leucine 
• 69425-35-0 N-(4-iodo-benzenesulfonyl)-aspartic acid 
• 6345-64-8 1,2-bis(4-Iodophenyl)disulfane 
• 56015-98-6 4-iodobenzenesulfinic acid 
• 2751-27-1 4-iodobenzenesulfonyl hydrazide 
• 825-86-5 4-iodo-benzenesulfonamide 
• 148901-06-8 N-(4'-iodophenylsulfonyl)-4-nitroaniline 
• 167156-20-9 N,N-diethyl-p-iodobenzenesulfonamide 
• 89976-48-7 N-(4-iodo-benzenesulfonyl)-glycine 
• 7454-83-3 4-iodo-benzenesulfonic acid o-toluidide 
• 378238-18-7 (S)-N-(p-iodophenylsulfonyl)proline 

Relevant academic research and scientific papers

Aromatic Chlorosulfonylation by Photoredox Catalysis

Visible-light photoredox catalysis enables the efficient synthesis of arenesulfonyl chlorides from anilines. The new protocol involves the convenient in situ preparation of arenediazonium salts (from anilines) and the reactive gases SO2and HCl (from aqueous SOCl2). The photocatalytic chlorosulfonylation operates at mild conditions (room temperature, acetonitrile/water) with low catalyst loading. Various functional groups are tolerated (e.g., halides, azides, nitro groups, CF3, SF5, esters, heteroarenes). Theoretical and experimental studies support a photoredox-catalysis mechanism.

Synthesis of aryl sulfonamides via palladium-catalyzed chlorosulfonylation of arylboronic acids

A palladium-catalyzed method for the preparation of sulfonamides is described. The process exhibits significant functional group tolerance and allows for the preparation of a number of arylsulfonyl chlorides and sulfonamides under mild conditions.

Preparation of nitrogen-containing 15-membered triolefinic macrocycles: (E,E,E)-1,6,11-tris(arylsulfonyl)-1,6,11-triazacyclopentadeca-3,8,13-trienes

Three routes to (E,E,E)-1,6,11-tris(arylsulfonyl)-1,6,11-triazacyclopentadeca-3,8,13-trienes are described. Optimization of the preparation of key intermediates has opened the way to efficient synthesis of a broad variety of 15-membered, nitrogen-containing triolefinic macrocycles.