methyl 2-(1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Base Information

Chemical Name:methyl 2-(1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate
CAS No.:1610370-17-6
Molecular Formula:C₂₈H₂₆F₄N₂O₃
Molecular Weight:514.52
Hs Code.:

Synonyms:methyl 2-(1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

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Chemical Property of methyl 2-(1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

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Technology Process of methyl 2-(1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

There total 13 articles about methyl 2-(1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1610370-13-2
2-(1-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

: 1610370-16-5
4′-(bromomethyl)-2-fluoro-5-methoxy-3′-methylbiphenyl

: 1610370-17-6
methyl 2-(1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: 4′-(bromomethyl)-2-fluoro-5-methoxy-3′-methylbiphenyl; With chloro-trimethyl-silane; ethylene dibromide; zinc; In tetrahydrofuran; at 65 ℃; for 2h; Inert atmosphere;

2-(1-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile; In tetrahydrofuran; at 20 - 80 ℃; Inert atmosphere;

Reference yield:

: 118096-36-9
N'-(4-bromophenyl)-2,2,2-trifluoroacetohydrazide

: 1610370-17-6
methyl 2-(1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 3 h / 0 - 20 °C

2.1: triethylamine / toluene / 40 °C

3.1: lithium borohydride / tetrahydrofuran / 3.5 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: triethylamine / dimethyl sulfoxide / 4 h / 60 °C

6.1: hydrogenchloride / dichloromethane; acetic acid methyl ester / 20 °C

7.1: zinc; ethylene dibromide; chloro-trimethyl-silane / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

7.2: 20 - 80 °C / Inert atmosphere

With hydrogenchloride; lithium borohydride; chloro-trimethyl-silane; ethylene dibromide; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; zinc; In tetrahydrofuran; dichloromethane; acetic acid methyl ester; dimethyl sulfoxide; ethyl acetate; toluene;

Reference yield:

: 589-21-9
(4-bromophenyl)hydrazine

: 1610370-17-6
methyl 2-(1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / 0 - 20 °C

2.1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 3 h / 0 - 20 °C

3.1: triethylamine / toluene / 40 °C

4.1: lithium borohydride / tetrahydrofuran / 3.5 h / 0 - 20 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C

6.1: triethylamine / dimethyl sulfoxide / 4 h / 60 °C

7.1: hydrogenchloride / dichloromethane; acetic acid methyl ester / 20 °C

8.1: zinc; ethylene dibromide; chloro-trimethyl-silane / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

8.2: 20 - 80 °C / Inert atmosphere

With hydrogenchloride; lithium borohydride; chloro-trimethyl-silane; ethylene dibromide; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; zinc; In tetrahydrofuran; dichloromethane; acetic acid methyl ester; dimethyl sulfoxide; ethyl acetate; toluene;