2-(1-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Base Information

Chemical Name:2-(1-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile
CAS No.:1610370-13-2
Molecular Formula:C₁₃H₁₂BrF₃N₂O₂
Molecular Weight:365.15
Hs Code.:

Synonyms:2-(1-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

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Chemical Property of 2-(1-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Chemical Property:

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Technology Process of 2-(1-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

There total 8 articles about 2-(1-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1610370-11-0
2-(1-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

: 1610370-13-2
2-(1-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: methanol; 2-(1-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile; With hydrogenchloride; In dichloromethane; acetic acid methyl ester; at 20 ℃;

With water; In methanol; dichloromethane; acetic acid methyl ester;

Reference yield:

: 589-21-9
(4-bromophenyl)hydrazine

: 1610370-13-2
2-(1-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 0 - 20 °C

2: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 3 h / 0 - 20 °C

3: triethylamine / toluene / 40 °C

4: lithium borohydride / tetrahydrofuran / 3.5 h / 0 - 20 °C

5: triethylamine / dichloromethane / 0 - 20 °C

6: triethylamine / dimethyl sulfoxide / 4 h / 60 °C

7: hydrogenchloride / dichloromethane; acetic acid methyl ester / 20 °C

With hydrogenchloride; lithium borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; In tetrahydrofuran; dichloromethane; acetic acid methyl ester; dimethyl sulfoxide; ethyl acetate; toluene;

Reference yield:

: 118096-36-9
N'-(4-bromophenyl)-2,2,2-trifluoroacetohydrazide

: 1610370-13-2
2-(1-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 3 h / 0 - 20 °C

2: triethylamine / toluene / 40 °C

3: lithium borohydride / tetrahydrofuran / 3.5 h / 0 - 20 °C

4: triethylamine / dichloromethane / 0 - 20 °C

5: triethylamine / dimethyl sulfoxide / 4 h / 60 °C

6: hydrogenchloride / dichloromethane; acetic acid methyl ester / 20 °C

With hydrogenchloride; lithium borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; In tetrahydrofuran; dichloromethane; acetic acid methyl ester; dimethyl sulfoxide; ethyl acetate; toluene;