diethyl N-<4-prop-2-ynylamino>benzoyl>-L-aspartate

Base Information

Chemical Name:diethyl N-<4-prop-2-ynylamino>benzoyl>-L-aspartate
CAS No.:80014-78-4
Molecular Formula:C₂₇H₂₉N₅O₆
Molecular Weight:519.557
Hs Code.:

diethyl N-<4-<N-<(2-amino-4-hydroxy-6-quinazolinyl)methyl>prop-2-ynylamino>benzoyl>-L-aspartate

Synonyms:diethyl N-<4-prop-2-ynylamino>benzoyl>-L-aspartate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl N-<4-prop-2-ynylamino>benzoyl>-L-aspartate

Chemical Property:

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Technology Process of diethyl N-<4-prop-2-ynylamino>benzoyl>-L-aspartate

There total 5 articles about diethyl N-<4-prop-2-ynylamino>benzoyl>-L-aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 77766-62-2
2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide

: 80014-88-6
diethyl N-<4-(prop-2-ynylamino)benzoyl>-L-aspartate

: 80014-78-4
diethyl N-<4-prop-2-ynylamino>benzoyl>-L-aspartate

Guidance literature:: With calcium carbonate; In various solvent(s); for 96h; Ambient temperature;
DOI:10.1021/jm00156a033

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 80014-78-4
diethyl N-<4-prop-2-ynylamino>benzoyl>-L-aspartate

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / pyridine / toluene / 1.) 0 deg C, 30 min, 2.) RT, 1 h

2: 97 percent / H₂ / 10percent Pd/C / ethanol / 760 Torr

3: 52 percent / 2,6-lutidine / various solvent(s) / 48 h / Ambient temperature

4: 48 percent / CaCO₃ / various solvent(s) / 96 h / Ambient temperature

With pyridine; 2,6-dimethylpyridine; hydrogen; calcium carbonate; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm00156a033

Reference yield:

: 16115-68-7
diethyl L-aspartate hydrochloride

: 80014-78-4
diethyl N-<4-prop-2-ynylamino>benzoyl>-L-aspartate

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / pyridine / toluene / 1.) 0 deg C, 30 min, 2.) RT, 1 h

2: 97 percent / H₂ / 10percent Pd/C / ethanol / 760 Torr

3: 52 percent / 2,6-lutidine / various solvent(s) / 48 h / Ambient temperature

4: 48 percent / CaCO₃ / various solvent(s) / 96 h / Ambient temperature

With pyridine; 2,6-dimethylpyridine; hydrogen; calcium carbonate; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm00156a033