benzyl [(5R)-5-[(tert-butoxycarbonyl)amino]-6-((4-[(6-methoxyquinolin-8-yl)amino]-pentyl)amino)-6-oxohexyl]carbamate

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Chemical Name:benzyl [(5R)-5-[(tert-butoxycarbonyl)amino]-6-((4-[(6-methoxyquinolin-8-yl)amino]-pentyl)amino)-6-oxohexyl]carbamate
CAS No.:1267638-23-2
Molecular Formula:C₃₄H₄₇N₅O₆
Molecular Weight:621.777
Hs Code.:

Synonyms:benzyl [(5R)-5-[(tert-butoxycarbonyl)amino]-6-((4-[(6-methoxyquinolin-8-yl)amino]-pentyl)amino)-6-oxohexyl]carbamate

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Chemical Property of benzyl [(5R)-5-[(tert-butoxycarbonyl)amino]-6-((4-[(6-methoxyquinolin-8-yl)amino]-pentyl)amino)-6-oxohexyl]carbamate

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Technology Process of benzyl [(5R)-5-[(tert-butoxycarbonyl)amino]-6-((4-[(6-methoxyquinolin-8-yl)amino]-pentyl)amino)-6-oxohexyl]carbamate

There total 1 articles about benzyl [(5R)-5-[(tert-butoxycarbonyl)amino]-6-((4-[(6-methoxyquinolin-8-yl)amino]-pentyl)amino)-6-oxohexyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 90-34-6,57152-58-6
Primaquine

: 55878-47-2
(R)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid

: 1267638-23-2
benzyl [(5R)-5-[(tert-butoxycarbonyl)amino]-6-((4-[(6-methoxyquinolin-8-yl)amino]-pentyl)amino)-6-oxohexyl]carbamate

Guidance literature:: With diisopropyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 4h;
DOI:10.1016/j.bmc.2010.11.036

Reference yield: 89.0%

: 1267638-23-2
benzyl [(5R)-5-[(tert-butoxycarbonyl)amino]-6-((4-[(6-methoxyquinolin-8-yl)amino]-pentyl)amino)-6-oxohexyl]carbamate

: 1267638-39-0
benzyl ((5R)-5-amino-6-[(4-((6-methoxyquinolin-8-yl)amino)pentyl)amino]-6-oxohexyl)carbamate

Guidance literature:: benzyl [(5R)-5-[(tert-butoxycarbonyl)amino]-6-((4-[(6-methoxyquinolin-8-yl)amino]-pentyl)amino)-6-oxohexyl]carbamate; With hydrogenchloride; In methanol; at 20 ℃; for 0.75h;

With ammonium hydroxide; In water;
DOI:10.1016/j.ejmech.2012.03.019

Reference yield:

: 1267638-23-2
benzyl [(5R)-5-[(tert-butoxycarbonyl)amino]-6-((4-[(6-methoxyquinolin-8-yl)amino]-pentyl)amino)-6-oxohexyl]carbamate

: 1267638-54-9
benzyl {(5R)-6-({4-[(6-methoxyquinolin-8-yl)amino]pentyl}amino)-5-[({4-[(6-methoxyquinolin-8-yl)amino]pentyl}carbamoyl)amino]-6-oxohexyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; methanol / 0.75 h / 20 °C

2.1: dichloromethane / 0.5 h / 20 °C

2.2: 5 h / 20 °C

With hydrogenchloride; methanol; In dichloromethane;
DOI:10.1016/j.bmc.2010.11.036