N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl}-2-methylpropyl-4-(4-hydroxyphenoxy)benzamide

Base Information

Chemical Name:N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl}-2-methylpropyl-4-(4-hydroxyphenoxy)benzamide
CAS No.:1436378-63-0
Molecular Formula:C₂₉H₃₅N₃O₄
Molecular Weight:489.615
Hs Code.:

Synonyms:N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl}-2-methylpropyl-4-(4-hydroxyphenoxy)benzamide

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Chemical Property of N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl}-2-methylpropyl-4-(4-hydroxyphenoxy)benzamide

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Technology Process of N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl}-2-methylpropyl-4-(4-hydroxyphenoxy)benzamide

There total 10 articles about N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl}-2-methylpropyl-4-(4-hydroxyphenoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332870-59-3
3-{(2S)-4-[(2S)-2-amino-3-methylbutyl]-2-methylpiperazin-1-yl}phenol

: 500-76-5
4-(4-hydroxyphenoxy)benzoic acid

: 1436378-63-0
N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl}-2-methylpropyl-4-(4-hydroxyphenoxy)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 12h;
DOI:10.1021/jm400275h

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 1436378-63-0
N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl}-2-methylpropyl-4-(4-hydroxyphenoxy)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / tetrahydrofuran / 2 h / 0 °C

2: borane-THF / tetrahydrofuran / Reflux

3: hydrogenchloride / water / 1 h

4: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h

With hydrogenchloride; borane-THF; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm400275h

Reference yield:

: C₂₁H₃₃N₃O₄

: 1436378-63-0
N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl}-2-methylpropyl-4-(4-hydroxyphenoxy)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / Reflux

2: hydrogenchloride / water / 1 h

3: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h

With hydrogenchloride; borane-THF; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm400275h