tert-butyl (3-bromo-6-methylpyrazolo[5,1-b][1,3]thiazol-7-yl)carbamate

Base Information

Chemical Name:tert-butyl (3-bromo-6-methylpyrazolo[5,1-b][1,3]thiazol-7-yl)carbamate
CAS No.:1401964-88-2
Molecular Formula:C₂₁H₂₇N₃O₅S
Molecular Weight:433.528
Hs Code.:

Synonyms:tert-butyl (3-bromo-6-methylpyrazolo[5,1-b][1,3]thiazol-7-yl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (3-bromo-6-methylpyrazolo[5,1-b][1,3]thiazol-7-yl)carbamate

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Technology Process of tert-butyl (3-bromo-6-methylpyrazolo[5,1-b][1,3]thiazol-7-yl)carbamate

There total 5 articles about tert-butyl (3-bromo-6-methylpyrazolo[5,1-b][1,3]thiazol-7-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 685886-67-3
[2,6-dimethoxy-4-(methoxymethyl)phenyl]boronic acid

: 1290127-80-8
tert-butyl (3-bromo-6-methylpyrazolo[5,1-b][1,3]thiazol-7-yl)carbamate

: 1401964-88-2
tert-butyl (3-bromo-6-methylpyrazolo[5,1-b][1,3]thiazol-7-yl)carbamate

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 90 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/jm300864p

Reference yield:

: 52197-84-9
1-(6-methylpyrazolo[5,1-b][1,3]thiazol-7-yl)ethanone

: 1401964-88-2
tert-butyl (3-bromo-6-methylpyrazolo[5,1-b][1,3]thiazol-7-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / water / 0 - 20 °C

2.1: hydrogenchloride; zinc / 1.25 h / 20 °C

3.1: triethylamine / dichloromethane / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C

4.2: 2 h / -78 - 20 °C

5.1: palladium diacetate; potassium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / 1.5 h / 90 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; zinc; sodium nitrite; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; water; 5.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm300864p

Reference yield:

: C₆H₅N₃O₂S

: 1401964-88-2
tert-butyl (3-bromo-6-methylpyrazolo[5,1-b][1,3]thiazol-7-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; zinc / 1.25 h / 20 °C

2.1: triethylamine / dichloromethane / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C

3.2: 2 h / -78 - 20 °C

4.1: palladium diacetate; potassium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / 1.5 h / 90 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; water; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm300864p