ethyl 5-(3-methoxybenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate

Base Information

Chemical Name:ethyl 5-(3-methoxybenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate
CAS No.:1340474-37-4
Molecular Formula:C₂₁H₂₇NO₆
Molecular Weight:389.448
Hs Code.:

Synonyms:ethyl 5-(3-methoxybenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate

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Chemical Property of ethyl 5-(3-methoxybenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate

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Technology Process of ethyl 5-(3-methoxybenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate

There total 4 articles about ethyl 5-(3-methoxybenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.4%

: 1071788-66-3
ethyl 5-bromomethyl-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate

: 10365-98-7,1107579-37-2
3-methoxyphenylboronic acid

: 1340474-37-4
ethyl 5-(3-methoxybenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate

Guidance literature:: With palladium diacetate; potassium carbonate; johnphos; In N,N-dimethyl-formamide; at 140 ℃; for 0.341667h; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.tetlet.2011.08.096

Reference yield:

: 126-30-7
2,2-Dimethyl-1,3-propanediol

: 1340474-37-4
ethyl 5-(3-methoxybenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / benzene / 18 h / Reflux

2: N-Bromosuccinimide / tetrachloromethane / 24 h / Mercury lamp irradiation

3: palladium diacetate; potassium carbonate; johnphos / N,N-dimethyl-formamide / 0.34 h / 140 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; palladium diacetate; potassium carbonate; toluene-4-sulfonic acid; johnphos; In tetrachloromethane; N,N-dimethyl-formamide; benzene; 3: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.tetlet.2011.08.096

Reference yield:

: 216962-12-8
3-isoxazolecarboxylic acid 5-methyl-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-ethyl ester

: 1340474-37-4
ethyl 5-(3-methoxybenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / tetrachloromethane / 24 h / Mercury lamp irradiation

2: palladium diacetate; potassium carbonate; johnphos / N,N-dimethyl-formamide / 0.34 h / 140 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; palladium diacetate; potassium carbonate; johnphos; In tetrachloromethane; N,N-dimethyl-formamide; 2: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.tetlet.2011.08.096