(2R,5S)-(+)-2-n-butyl-5-(4-oxopentyl)pyrrolidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(2R,5S)-(+)-2-n-butyl-5-(4-oxopentyl)pyrrolidine-1-carboxylic acid benzyl ester
CAS No.:136092-35-8
Molecular Formula:C₂₁H₃₁NO₃
Molecular Weight:345.482
Hs Code.:

Synonyms:(2R,5S)-(+)-2-n-butyl-5-(4-oxopentyl)pyrrolidine-1-carboxylic acid benzyl ester

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Chemical Property of (2R,5S)-(+)-2-n-butyl-5-(4-oxopentyl)pyrrolidine-1-carboxylic acid benzyl ester

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Technology Process of (2R,5S)-(+)-2-n-butyl-5-(4-oxopentyl)pyrrolidine-1-carboxylic acid benzyl ester

There total 12 articles about (2R,5S)-(+)-2-n-butyl-5-(4-oxopentyl)pyrrolidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1034498-80-0
(2R,5S)-(+)-2-n-butyl-5-(4-pentenyl)pyrrolidine-1-carboxylic acid benzyl ester

: 136092-35-8
(2R,5S)-(+)-2-n-butyl-5-(4-oxopentyl)pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With oxygen; copper(l) chloride; palladium dichloride; In water; N,N-dimethyl-formamide; at 20 ℃; for 18h; under 760.051 Torr;
DOI:10.1021/jo800593n

Reference yield: 80.0%

: 136092-34-7
(2R,5R)-2-Butyl-5-((E)-4-oxo-pent-2-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

: 136092-35-8
(2R,5S)-(+)-2-n-butyl-5-(4-oxopentyl)pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With hydrogen; platinum(IV) oxide; In methanol; under 760 Torr;
DOI:10.1016/S0040-4039(00)92707-2

Reference yield:

: 51693-17-5
(S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester

: 136092-35-8
(2R,5S)-(+)-2-n-butyl-5-(4-oxopentyl)pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 61 percent / diethyl ether; CH₂Cl₂ / -30 °C

3: Ni(acac)2 / CHCl₃

4: NaOMe

5: 76 percent / H₂, HCl / Raney Ni / methanol / 75005.9 Torr

6: LiAlH₄ / diethyl ether

8: PCC / CH₂Cl₂

9: 78 percent / tetrahydrofuran / Heating

10: 80 percent / H₂ / PtO₂ / methanol / 760 Torr

With hydrogenchloride; bis(acetylacetonate)nickel(II); lithium aluminium tetrahydride; hydrogen; sodium methylate; pyridinium chlorochromate; platinum(IV) oxide; nickel; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform;
DOI:10.1016/S0040-4039(00)92707-2