51693-17-5

Basic information

• Product Name: (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate
• Synonyms: (S)-(+)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE P-TOLUENESULFONATE;(S)-5-HYDROXYMETHYL-2-PYRROLIDINONE P-TOLUENESULFONATE;(-)-L-PYROGLUTAMOL P-TOLUENESULFONATE;(S)-(+)-5-(hydroxymethyl)-2-pyrrolidinone P-tolu;TOLUENE-4-SULFONIC ACID (S)-5-OXO-PYRROLIDIN-2-YLMETHYL ESTER;>98%ee;(S)-(+)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE P-TOLUENESULFONATE 95%;(R)-(5-OXOPYRROLIDIN-2-YL)METHYL 4-METHYLBENZENESULFONATE
• CAS NO: 51693-17-5
• Molecular Formula: C₁₂H₁₅NO₄S
• Molecular Weight: 269.32
• Product Categories: Chiral Building Blocks;Heterocyclic Building Blocks;Pyrrolidines
• Mol File: 51693-17-5.mol
• Article Data: 49

Chemical Properties

• Melting Point: 124-128 °C(lit.)
• Boiling Point: 504.8 °C at 760 mmHg
• Flash Point: 259.1 °C
• Appearance: Colorless to beige/Powder
• Density: 1.275 g/cm³
• Vapor Pressure: 2.58E-10mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: Refrigerator (+4°C)
• PKA: 15.34±0.40(Predicted)
• CAS DataBase Reference: (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate(51693-17-5)
• EPA Substance Registry System: (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate(51693-17-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 51693-17-5(Hazardous Substances Data)

Usage

Chemical Properties

colorless to beige powder

Uses

Serves as a building block in the synthesis of (R)- and (S)-diaminovaleric acids and of 5-azasemicorrin bidentate nitrogen ligands for enantioselective catalysis.

InChI:InChI=1/C12H15NO4S/c1-9-2-5-11(6-3-9)18(15,16)17-8-10-4-7-12(14)13-10/h2-3,5-6,10H,4,7-8H2,1H3,(H,13,14)/t10-/m0/s1

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 98-79-3 L-Pyroglutamic acid 
• 56-86-0 L-glutamic acid 
• 32503-27-8 tetra(n-butyl)ammonium hydrogensulfate 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 4931-66-2 methyl (S)-pyroglutamate 
• 17342-08-4 (S)-Pyroglutaminol 

Downstream Products

• 307309-37-1 (S)-5-(4-nitrophenoxymethyl)pyrrolidin-2-one 
• 72479-06-2 2-[(2S)-5-oxopyrrolidin-2-yl]acetonitrile 
• 108-27-0 5-methylpyrrolidin-2-one 
• 72479-05-1 (S)-(-)-5-(Bromomethyl)-2-pyrrolidinone 
• 145414-31-9 (S)-5-aminomethyl-2-pyrrolidone 
• 1431873-32-3 C₃₀H₃₉N₇O₄Si 
• 1431873-33-4 C₃₀H₃₉N₇O₄Si 
• 1431873-31-2 (S)-(5-oxo-1-((2-(trimethylsilyl)ethoxy)methyl)pyrrolidin-2-yl)methyl 4-methylbenzenesulfonate 
• 1431871-38-3 C₂₃H₂₁Cl₂N₇O₂ 
• 1431871-39-4 C₂₃H₂₁Cl₂N₇O₂ 
• 1431871-06-5 C₂₄H₂₃F₂N₇O₃ 
• 1431871-07-6 C₂₄H₂₃F₂N₇O₃ 
• 1431871-03-2 C₂₄H₂₄FN₇O₃ 
• 1431871-02-1 C₂₄H₂₄FN₇O₃ 

Relevant articles and documents

Synthesis of N-aminomethylpyrrolidin-2-ones

Pyrrolidin-2-ones react with formaldehyde and chlorotrimethylsilane to give 1-chloromethylpyrrolidin-2-ones which upon subsequent reaction with primary and secondary amines give 1-aminomethylpyrrolidin-2-ones in good yield.

NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE

Described herein are new, selective modulators of the 5 -HT7 receptor. These selective compounds can be useful for the treatment of CNS and non-CNS indications. Compounds described herein can be selective in targeting 5-HT7 receptors

Synthesis of optically active (R)- And (S)-β-arginine from pyroglutamic acid

– The first synthesis of optically active β-arginine was achieved starting from commercially available pyroglutamic acid. The new synthetic protocol is characterized by the use of nitrile as a carboxylic acid surrogate which could be transformed to the co