1-(2-{[1,3-dioxo-2-(prop-2-en-1-yl)-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl]amino}ethyl)-3-phenylthiourea

Base Information

• Chemical Name: 1-(2-{[1,3-dioxo-2-(prop-2-en-1-yl)-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl]amino}ethyl)-3-phenylthiourea
• CAS No.: 1127232-14-7
• Molecular Formula: C₂₄H₂₂N₄O₂S
• Molecular Weight: 430.53
• Mol file: 1127232-14-7.mol

Synonyms:1-(2-{[1,3-dioxo-2-(prop-2-en-1-yl)-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl]amino}ethyl)-3-phenylthiourea

Chemical Property of 1-(2-{[1,3-dioxo-2-(prop-2-en-1-yl)-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl]amino}ethyl)-3-phenylthiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-{[1,3-dioxo-2-(prop-2-en-1-yl)-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl]amino}ethyl)-3-phenylthiourea

There total 5 articles about 1-(2-{[1,3-dioxo-2-(prop-2-en-1-yl)-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl]amino}ethyl)-3-phenylthiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-allyl-4-ethylenediamine-1,8-naphthalimide (951244-81-8) + phenyl isothiocyanate (103-72-0) → 1-(2-{[1,3-dioxo-2-(prop-2-en-1-yl)-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl]amino}ethyl)-3-phenylthiourea (1127232-14-7)

Guidance literature:

In chloroform; at 20 ℃; for 120h; Inert atmosphere;

DOI:10.1016/j.saa.2012.01.008

Reference yield:

5-bromoacenaphthene (2051-98-1) → 1-(2-{[1,3-dioxo-2-(prop-2-en-1-yl)-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl]amino}ethyl)-3-phenylthiourea (1127232-14-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium dichromate; acetic acid / 5 h / Reflux

2: ethanol / 4 h / Reflux

3: N,N-dimethyl-formamide / 5 h / Reflux

4: chloroform / 120 h / 20 °C / Inert atmosphere

With sodium dichromate; acetic acid; In ethanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.saa.2012.01.008

Reference yield:

acenaphthene (83-32-9) → 1-(2-{[1,3-dioxo-2-(prop-2-en-1-yl)-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl]amino}ethyl)-3-phenylthiourea (1127232-14-7)

Guidance literature:

Multi-step reaction with 5 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

2: sodium dichromate; acetic acid / 5 h / Reflux

3: ethanol / 4 h / Reflux

4: N,N-dimethyl-formamide / 5 h / Reflux

5: chloroform / 120 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; sodium dichromate; acetic acid; In ethanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.saa.2012.01.008

upstream raw materials:

N-allyl-4-ethylenediamine-1,8-naphthalimide

phenyl isothiocyanate

5-bromoacenaphthene

acenaphthene