2051-98-1Relevant articles and documents
Synthesis and application of novel heterocyclic dyes based on 11-Amino-3-Bromo-13H-acenaphtho[1,2-e]pyridazino[3,2-b]-quinazoline-13-one
Patel, Vijay H.,Patel, Manish P.,Patel, Ranjan G.
, p. 599 - 606 (2001)
Synthesized a new fused heterocyclic compound, 11-Amino-3-Bromo-13H-acenaphtho[1,2-e]pyridazino[3,2-b]-quinazoline-13-one and is used to synthesize a novel series of heterocyclic mono azo dyes by coupling with various naphthols. All the dyes were characterized by their percentage yield, melting point, UV-visible spectroscopy, elemental analysis, infrared spectroscopy and dyeing performance on nylon 66 and polyester fibres. The percentage dye bath exhaustion on different fibres has been found to be reasonably good and acceptable. The dyed fibres showed fair to fairly good fastness to light and very good to excellent fastness to washing, rubbing, perspiration and sublimation.
Synthesis of naphthalimide-phenanthro[9,10-d]imidazole derivatives: In vitro evaluation, binding interaction with DNA and topoisomerase inhibition
Luxami, Vijay,Paul, Kamaldeep,Singh, Iqubal
, (2020)
The synthesis and characterization of a series of naphthalimide and phenanthro[9,10-d]imidazole conjugate is described. These compounds are evaluated in vitro for their cytotoxicity towards 60 human cancer cell lines. Derivative 16 shows excellent cytotoxic activity against these cancer cell lines with the range of growth inhibition from ?55.78 to 94.53. The most potent derivative (ethylpiperazine, 16) is further studied to evaluate the interaction with ct-DNA using absorption and emission spectroscopy as well as DNA viscosity measurement. The DNA binding studies indicate that compound 16 is significantly interacted with DNA through groove binding having binding constant value of 7.81 × 104 M?1 alongwith partial intercalation between the base pairs of DNA strands. Further, topoisomerase inhibition study suggests that compound 16 is induced apoptosis and inhibits human topoisomerase (Topo-IIα) as a possible intracellular target. Molecular docking study of compound 16 with ct-DNA shows good docking score.
Electron-poor bowl-shaped polycyclic aromatic dicarboximides: Synthesis, crystal structures, and optical and redox properties
Shoyama, Kazutaka,Schmidt, David,Mahl, Magnus,Würthner, Frank
, p. 5328 - 5331 (2017)
Two new bowl-shaped polycyclic aromatic hydrocarbons, based on corannulene and naphthalene dicarboximide, are synthesized by an improved Suzuki-Miyaura cross-coupling and C-H arylation cascade reaction. Crystallographic analyses confirm structural assignments and provide insight into molecular interactions in the solid state. The new bowl-shaped molecules show reversible oxidation and reduction, intense visible range absorption, and high fluorescence quantum yields. These molecules can be considered bowl-shaped congeners of planar perylene dicarboximides.
Functionalization of poly(amidoamine) dendrimer-based nano-architectures using a naphthalimide derivative and their fluorescent, dyeing and antimicrobial properties on wool fibers
Sadeghi-Kiakhani, Mousa,Safapour, Siyamak
, p. 1005 - 1012 (2016)
Novel naphthalimide-poly(amidoamine) dendrimer fluorescent dyes were synthesized, and their structures were identified and confirmed using different characterization methods such as Fourier transform infrared, 1H NMR, 13C NMR, differential scanning calorimetry, elemental analysis and UV-vis spectroscopy. The spectrophotometric studies demonstrated absorption maxima (λmax) and extinction coefficient (max) values in the ranges of 429-438 nm and 25,635-88,618 L/mol/cm, respectively. The dyeing, fastness and antimicrobial properties of dyed wool fibers were examined. Colorimetric measurements demonstrated a greenish-yellow hue with remarkable fluorescence intensity on dyed wool. Although the fastness properties of naphthalimide dye on wool fibers were poor/moderate, color fastness was appreciably improved through modification of the dye using dendrimers. The results revealed that the newly synthesized dyes are potent antimicrobial agents on wool fibers. Overall, it was deduced that poly(amidoamine) (PAMAM) dendrimers could be exploited as a promising tool in tailoring the different properties of naphthalimide dyes, being suitable for dyeing and antimicrobial finishing agents for wool fibers.
Naphthalimide-based optical turn-on sensor for monosaccharide recognition using boronic acid receptor
Seraj, Sanaz,Rouhani, Shohre,Faridbod, Farnoush
, p. 17933 - 17940 (2019)
A highly selective and sensitive fluorescent sensor for the determination of fructose is developed. The fluorescent sensor was prepared by incorporating a new naphthalimide dye with a planar structure as a selectophore and graphene oxide (GO) nanoplatelets as a quencher for rapid optical detection of fructose. The designed probe, made with the high fusion loop-containing dye, along with the GO nanoplatelets, detected fructose over the other monosaccharides very well. The proposed sensor displays a linear response range of 7 × 10-5 to 3 × 10-2 M with a low limit of detection of 23 × 10-6 M in solution at pH 7.4. This sensor shows a good selectivity towards fructose with respect to other saccharides. The proposed sensor was then applied to the determination of fructose in human plasma with satisfactory results.
Preparation method 4 - bromo -5 - nitro -1, 8 - naphthalene anhydride (by machine translation)
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Paragraph 0021-0031, (2020/07/15)
The invention belongs to the technical field of fine chemical engineering, and concretely relates to 4 - bromo -5 - nitro -1, 8 - naphthalene anhydride preparation method. 5 - Bromoacenaphthylene is added dropwise to obtain 5 - bromo 4 - nitroacenaphthylene;5 - bromo 4 - nitroacenaphthylene and a catalyst are added into glacial acetic acid to react to obtain -5 - bromo 4 - nitro -5 - and -1 8 - naphthalene anhydride. The method for preparing the target product has the advantages of cheap and easily available raw materials, low preparation cost, high product yield, mild preparation process conditions, good atomic economy and industrial mass production. (by machine translation)
