N-[2-oxo-2-(thietan-3-ylamino)ethyl]-4-[3-(3,4,5-trichlorophenyl)-3-(trifluoro-methyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-trifluoromethylbenzamide

Base Information

Chemical Name:N-[2-oxo-2-(thietan-3-ylamino)ethyl]-4-[3-(3,4,5-trichlorophenyl)-3-(trifluoro-methyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-trifluoromethylbenzamide
CAS No.:1303518-29-7
Molecular Formula:C₂₄H₁₈Cl₃F₆N₃O₂S
Molecular Weight:632.841
Hs Code.:

Synonyms:N-[2-oxo-2-(thietan-3-ylamino)ethyl]-4-[3-(3,4,5-trichlorophenyl)-3-(trifluoro-methyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-trifluoromethylbenzamide

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Chemical Property of N-[2-oxo-2-(thietan-3-ylamino)ethyl]-4-[3-(3,4,5-trichlorophenyl)-3-(trifluoro-methyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-trifluoromethylbenzamide

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Technology Process of N-[2-oxo-2-(thietan-3-ylamino)ethyl]-4-[3-(3,4,5-trichlorophenyl)-3-(trifluoro-methyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-trifluoromethylbenzamide

There total 12 articles about N-[2-oxo-2-(thietan-3-ylamino)ethyl]-4-[3-(3,4,5-trichlorophenyl)-3-(trifluoro-methyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 943437-99-8
thietan-3-yl amine hydrobromide

: 1303518-33-3
N-{4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)-benzoyl}glycine

: 1303518-29-7
N-[2-oxo-2-(thietan-3-ylamino)ethyl]-4-[3-(3,4,5-trichlorophenyl)-3-(trifluoro-methyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-trifluoromethylbenzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 261952-01-6
4-methyl-3-(trifluoromethyl)benzoic acid

: 1303518-29-7
N-[2-oxo-2-(thietan-3-ylamino)ethyl]-4-[3-(3,4,5-trichlorophenyl)-3-(trifluoro-methyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 12 steps

1: N-Bromosuccinimide / tetrachloromethane / 1 h / Reflux; UV-irradiation

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

3: silver nitrate / ethanol; water / 2 h / Reflux

4: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 20 °C

5: methanesulfonyl chloride / 1,2-dichloro-ethane / 5.33 h / Cooling with ice; Reflux

6: Lawessons reagent / toluene / 1 h / 85 °C

7: potassium tert-butylate / tetrahydrofuran / 0.5 h / -60 °C

8: tetrabutyl ammonium fluoride / tetrahydrofuran / 20.5 h / -5 - 20 °C / Inert atmosphere

9: sulfuric acid; acetic acid / water / 26 h / Reflux

10: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C

11: sodium hydroxide; water / ethanol / 20 °C

12: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

With Lawessons reagent; N-Bromosuccinimide; sulfuric acid; hydroxylamine hydrochloride; potassium tert-butylate; tetrabutyl ammonium fluoride; water; sodium acetate; benzotriazol-1-ol; silver nitrate; acetic acid; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1303518-45-7
4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoic acid

: 1303518-29-7
N-[2-oxo-2-(thietan-3-ylamino)ethyl]-4-[3-(3,4,5-trichlorophenyl)-3-(trifluoro-methyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C

2: sodium hydroxide; water / ethanol / 20 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;