4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoic acid

Base Information

Chemical Name:4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoic acid
CAS No.:1303518-45-7
Molecular Formula:C₁₉H₁₀Cl₃F₆NO₂
Molecular Weight:504.643
Hs Code.:

Synonyms:4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoic acid

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Chemical Property of 4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoic acid

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Technology Process of 4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoic acid

There total 9 articles about 4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1303518-43-5
4-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoro-methyl)benzonitrile

: 1303518-45-7
4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoic acid

Guidance literature:: With sulfuric acid; acetic acid; In water; for 26h; Reflux;

Reference yield:

: 1303518-38-8
4-formyl-3-(trifluoromethyl)-N-[(trimethylsilyl)methyl]benzamide

: 1303518-45-7
4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 20 °C

2: methanesulfonyl chloride / 1,2-dichloro-ethane / 5.33 h / Cooling with ice; Reflux

3: Lawessons reagent / toluene / 1 h / 85 °C

4: potassium tert-butylate / tetrahydrofuran / 0.5 h / -60 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 20.5 h / -5 - 20 °C / Inert atmosphere

6: sulfuric acid; acetic acid / water / 26 h / Reflux

With Lawessons reagent; sulfuric acid; hydroxylamine hydrochloride; potassium tert-butylate; tetrabutyl ammonium fluoride; sodium acetate; acetic acid; methanesulfonyl chloride; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1303518-36-6
4-(dibromomethyl)-3-(trifluoromethyl)-N-[(trimethylsilyl)methyl]benzamide

: 1303518-45-7
4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: silver nitrate / ethanol; water / 2 h / Reflux

2: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 20 °C

3: methanesulfonyl chloride / 1,2-dichloro-ethane / 5.33 h / Cooling with ice; Reflux

4: Lawessons reagent / toluene / 1 h / 85 °C

5: potassium tert-butylate / tetrahydrofuran / 0.5 h / -60 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 20.5 h / -5 - 20 °C / Inert atmosphere

7: sulfuric acid; acetic acid / water / 26 h / Reflux

With Lawessons reagent; sulfuric acid; hydroxylamine hydrochloride; potassium tert-butylate; tetrabutyl ammonium fluoride; sodium acetate; silver nitrate; acetic acid; methanesulfonyl chloride; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; toluene;