tert-butyl 3-(9-oxo-10-(3-(trifluoromethyl)phenyl)-9,10-dihydropyrido[3,2-c][1,5]naphthyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-1-carboxylate

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Chemical Name:tert-butyl 3-(9-oxo-10-(3-(trifluoromethyl)phenyl)-9,10-dihydropyrido[3,2-c][1,5]naphthyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-1-carboxylate
CAS No.:1416000-85-5
Molecular Formula:C₃₀H₂₂F₃N₅O₃
Molecular Weight:557.532
Hs Code.:

Synonyms:tert-butyl 3-(9-oxo-10-(3-(trifluoromethyl)phenyl)-9,10-dihydropyrido[3,2-c][1,5]naphthyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-1-carboxylate

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Chemical Property of tert-butyl 3-(9-oxo-10-(3-(trifluoromethyl)phenyl)-9,10-dihydropyrido[3,2-c][1,5]naphthyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-1-carboxylate

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Technology Process of tert-butyl 3-(9-oxo-10-(3-(trifluoromethyl)phenyl)-9,10-dihydropyrido[3,2-c][1,5]naphthyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-1-carboxylate

There total 10 articles about tert-butyl 3-(9-oxo-10-(3-(trifluoromethyl)phenyl)-9,10-dihydropyrido[3,2-c][1,5]naphthyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

: 942070-47-5
2-methyl-2-propanyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

: 1416000-57-1
2-chloro-10-(3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one

: 1416000-85-5
tert-butyl 3-(9-oxo-10-(3-(trifluoromethyl)phenyl)-9,10-dihydropyrido[3,2-c][1,5]naphthyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-1-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; for 6h; Inert atmosphere; Reflux;

Reference yield: 95.2%

: 1416000-85-5
tert-butyl 3-(9-oxo-10-(3-(trifluoromethyl)phenyl)-9,10-dihydropyrido[3,2-c][1,5]naphthyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-1-carboxylate

Guidance literature:: With sodium carbonate; In dichloromethane;

Reference yield:

: 4487-59-6
2-bromo-5-nitropyridine

: 1416000-85-5
tert-butyl 3-(9-oxo-10-(3-(trifluoromethyl)phenyl)-9,10-dihydropyrido[3,2-c][1,5]naphthyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: iron; hydrogenchloride / ethanol; water / 5 h / Reflux

2: ethanol / 5 h / Reflux

3: diphenylether / 0.75 h / Reflux

4: dimethyl amine; trichlorophosphate / 3 h / Reflux

5: potassium carbonate / tert-butyl alcohol / 3 h / Reflux

6: sodium tetrahydroborate; ethanol / 24 h / 20 °C

7: manganese(IV) oxide / dichloromethane / 8 h / 20 °C

8: potassium carbonate / tert-butyl alcohol / 36 h / 160 °C / Sealed tube

9: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 6 h / Inert atmosphere; Reflux

With hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; iron; sodium carbonate; potassium carbonate; dimethyl amine; trichlorophosphate; In diphenylether; ethanol; dichloromethane; water; toluene; tert-butyl alcohol;