(1R,2R,5R)-3-(4,5-Diphenyl-1,3-oxazol-2-ylmethylimino)-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol

Base Information

Chemical Name:(1R,2R,5R)-3-(4,5-Diphenyl-1,3-oxazol-2-ylmethylimino)-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol
CAS No.:328000-60-8
Molecular Formula:C₂₆H₂₈N₂O₂
Molecular Weight:400.521
Hs Code.:

Synonyms:(1R,2R,5R)-3-(4,5-Diphenyl-1,3-oxazol-2-ylmethylimino)-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol

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Chemical Property of (1R,2R,5R)-3-(4,5-Diphenyl-1,3-oxazol-2-ylmethylimino)-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol

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Technology Process of (1R,2R,5R)-3-(4,5-Diphenyl-1,3-oxazol-2-ylmethylimino)-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol

There total 3 articles about (1R,2R,5R)-3-(4,5-Diphenyl-1,3-oxazol-2-ylmethylimino)-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 33162-00-4
2-Aminomethyl-4,5-diphenyl-1,3-oxazole

: 1845-25-6,10136-65-9,20536-50-9,73466-08-7,84236-04-4,125073-44-1,24047-72-1
(-)-(2R,3R,5R)-2-hydroxy-3-pinanone

: 328000-60-8
(1R,2R,5R)-3-(4,5-Diphenyl-1,3-oxazol-2-ylmethylimino)-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol

Guidance literature:: With 4 A molecular sieve; boron trifluoride diethyl etherate; In toluene; Heating;
DOI:10.1055/s-2000-8719

Reference yield:

: 328000-89-1
4,5-Diphenyl-2-phthalimidomethyl-1,3-oxazole

: 328000-60-8
(1R,2R,5R)-3-(4,5-Diphenyl-1,3-oxazol-2-ylmethylimino)-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / hydrazine hydrate / ethanol / 2 h / Heating

2: 75 percent / BF₃*OEt₂; 4 Angstroem molecular sieves / toluene / Heating

With 4 A molecular sieve; boron trifluoride diethyl etherate; hydrazine hydrate; In ethanol; toluene; 1: Substitution / 2: Condensation;
DOI:10.1055/s-2000-8719

Reference yield:

: 81819-14-9
(4,5-diphenyloxazol-2-yl)methyl bromide

: 328000-60-8
(1R,2R,5R)-3-(4,5-Diphenyl-1,3-oxazol-2-ylmethylimino)-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / ethanol / 5 h / Heating

2: 98 percent / hydrazine hydrate / ethanol / 2 h / Heating

3: 75 percent / BF₃*OEt₂; 4 Angstroem molecular sieves / toluene / Heating

With 4 A molecular sieve; boron trifluoride diethyl etherate; hydrazine hydrate; In ethanol; toluene; 1: Alkylation / 2: Substitution / 3: Condensation;
DOI:10.1055/s-2000-8719