tert-butyl 4-(7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl)-piperazine-1-carboxylate

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Chemical Name:tert-butyl 4-(7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl)-piperazine-1-carboxylate
CAS No.:888615-20-1
Molecular Formula:C₂₆H₃₃ClN₈O₂
Molecular Weight:525.053
Hs Code.:

Synonyms:tert-butyl 4-(7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl)-piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl)-piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl)-piperazine-1-carboxylate

There total 1 articles about tert-butyl 4-(7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl)-piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 109577-83-5
7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine

: 888615-20-1
tert-butyl 4-(7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl)-piperazine-1-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 1.5h;

Reference yield: 90.0%

: 888615-20-1
tert-butyl 4-(7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl)-piperazine-1-carboxylate

: 926-62-5
isobutylmagnesium bromide

: 944044-11-5
tert-butyl 4-(7-benzylamino-6-isobutyl-4-pyrrolidin-1-yl-pteridin-2-yl)-piperazine-1-carboxylate

Guidance literature:: tert-butyl 4-(7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl)-piperazine-1-carboxylate; isobutylmagnesium bromide; iron-(III)-acetylacetonate; In 1-methyl-pyrrolidin-2-one; diethyl ether; at 0 - 20 ℃; for 1h;

With water; In 1-methyl-pyrrolidin-2-one; diethyl ether;

Reference yield: 13.0%

: 888615-20-1
tert-butyl 4-(7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl)-piperazine-1-carboxylate

: 124-41-4
sodium methylate

: benzyl-(6-methoxy-2-piperazin-1-yl-4-pyrrolidin-1-yl-pteridin-7-yl)-amine

Guidance literature:: tert-butyl 4-(7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl)-piperazine-1-carboxylate; sodium methylate; In tetrahydrofuran; at 120 ℃; for 0.1h; microwave;

With water; In dichloromethane;