(R,S)-α-cyano-3-phenoxyphenylacetonitrile

Base Information

• Chemical Name: (R,S)-α-cyano-3-phenoxyphenylacetonitrile
• CAS No.: 897445-61-3
• Molecular Formula: C₁₅H₁₀N₂O
• Molecular Weight: 234.257
• Mol file: 897445-61-3.mol

Synonyms:(R,S)-α-cyano-3-phenoxyphenylacetonitrile

Chemical Property of (R,S)-α-cyano-3-phenoxyphenylacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,S)-α-cyano-3-phenoxyphenylacetonitrile

There total 3 articles about (R,S)-α-cyano-3-phenoxyphenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phenoxy-benzoyl chloride (3586-15-0) + malononitrile (109-77-3) → (R,S)-α-cyano-3-phenoxyphenylacetonitrile (897445-61-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/jm4001314

Reference yield:

3-phenoxybenzoic acid (3739-38-6) → (R,S)-α-cyano-3-phenoxyphenylacetonitrile (897445-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; hexane / 1 h / 20 °C

2: sodium hydride / tetrahydrofuran / 1 h / 20 °C

With oxalyl dichloride; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1021/jm4001314

Reference yield:

2-chlorobenzylthiocyanate (2082-66-8) + 3-phenoxyphenylacetonitrile (51632-29-2) → (R,S)-α-cyano-3-phenoxyphenylacetonitrile (897445-61-3)

Guidance literature:

With lithium diisopropyl amide;

DOI:10.1016/j.bmcl.2004.01.012

upstream raw materials:

2-chlorobenzylthiocyanate

3-phenoxyphenylacetonitrile

3-phenoxy-benzoyl chloride

malononitrile

Downstream raw materials:

2-[methoxy-(3-phenoxy-phenyl)-methylene]-malononitrile

pyridine

3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid