(2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-phenyl-2-(phenylmethoxy)pentanal

Base Information

Chemical Name:(2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-phenyl-2-(phenylmethoxy)pentanal
CAS No.:862423-76-5
Molecular Formula:C₃₄H₃₈O₃Si
Molecular Weight:522.759
Hs Code.:

Synonyms:(2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-phenyl-2-(phenylmethoxy)pentanal

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Chemical Property of (2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-phenyl-2-(phenylmethoxy)pentanal

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Technology Process of (2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-phenyl-2-(phenylmethoxy)pentanal

There total 1 articles about (2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-phenyl-2-(phenylmethoxy)pentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 862423-84-5
(2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-N-methoxy-N-methyl-5-phenyl-2-(phenylmethoxy)pentamide

: 862423-76-5
(2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-phenyl-2-(phenylmethoxy)pentanal

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;
DOI:10.1021/ol051226f

Reference yield:

: 862423-73-2
4-methyl-1-(1,1,2,2-tetramethyl-1-silapropoxy)pentan-2-one

: 862423-76-5
(2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-phenyl-2-(phenylmethoxy)pentanal

: (5S,6S,7S,8R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-6-hydroxy-2-methyl-10-phenyl-7-(phenylmethoxy)-5-(1,1,2,2-tetramethyl-1-silapropoxy)decan-4-one

: 862423-78-7
(5R,6R,7S,8R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-6-hydroxy-2-methyl-10-phenyl-7-(phenylmethoxy)-5-(1,1,2,2-tetramethyl-1-silapropoxy)decan-4-one

Guidance literature:: 4-methyl-1-(1,1,2,2-tetramethyl-1-silapropoxy)pentan-2-one; With N,N-dimethyl-ethanamine; dicyclohexylboron chloride; In pentane; at 0 - 20 ℃;

(2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-phenyl-2-(phenylmethoxy)pentanal; In pentane; at -78 - -20 ℃; for 9h;

With phosphate buffer; dihydrogen peroxide; In methanol; water; at 20 ℃; for 1h; pH=7;
DOI:10.1021/ol051226f

Reference yield:

: 862423-76-5
(2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-phenyl-2-(phenylmethoxy)pentanal

: (2S,3R,4S,5S,6R)-5-Benzyloxy-2-isobutyl-6-phenethyl-tetrahydro-pyran-2,3,4-triol

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexylchloroborane; EtNMe₂ / pentane / 0 - 20 °C

1.2: pentane / 9 h / -78 - -20 °C

1.3: H₂O₂; phosphate buffer / methanol; H₂O / 1 h / 20 °C / pH 7

2.1: 58 percent / TBAF / tetrahydrofuran

With N,N-dimethyl-ethanamine; dicyclohexylboron chloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; pentane; 1.2: aldol reaction;
DOI:10.1021/ol051226f