(5R,6R,7S,8R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-6-hydroxy-2-methyl-10-phenyl-7-(phenylmethoxy)-5-(1,1,2,2-tetramethyl-1-silapropoxy)decan-4-one

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Chemical Name:(5R,6R,7S,8R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-6-hydroxy-2-methyl-10-phenyl-7-(phenylmethoxy)-5-(1,1,2,2-tetramethyl-1-silapropoxy)decan-4-one
CAS No.:862423-78-7
Molecular Formula:C₄₆H₆₄O₅Si₂
Molecular Weight:753.182
Hs Code.:

(5R,6R,7S,8R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-6-hydroxy-2-methyl-10-phenyl-7-(phenylmethoxy)-5-(1,1,2,2-tetramethyl-1-silapropoxy)decan-4-one

Synonyms:(5R,6R,7S,8R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-6-hydroxy-2-methyl-10-phenyl-7-(phenylmethoxy)-5-(1,1,2,2-tetramethyl-1-silapropoxy)decan-4-one

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Chemical Property of (5R,6R,7S,8R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-6-hydroxy-2-methyl-10-phenyl-7-(phenylmethoxy)-5-(1,1,2,2-tetramethyl-1-silapropoxy)decan-4-one

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Technology Process of (5R,6R,7S,8R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-6-hydroxy-2-methyl-10-phenyl-7-(phenylmethoxy)-5-(1,1,2,2-tetramethyl-1-silapropoxy)decan-4-one

There total 4 articles about (5R,6R,7S,8R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-6-hydroxy-2-methyl-10-phenyl-7-(phenylmethoxy)-5-(1,1,2,2-tetramethyl-1-silapropoxy)decan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 862423-73-2
4-methyl-1-(1,1,2,2-tetramethyl-1-silapropoxy)pentan-2-one

: 862423-76-5
(2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-phenyl-2-(phenylmethoxy)pentanal

: (5S,6S,7S,8R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-6-hydroxy-2-methyl-10-phenyl-7-(phenylmethoxy)-5-(1,1,2,2-tetramethyl-1-silapropoxy)decan-4-one

: 862423-78-7
(5R,6R,7S,8R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-6-hydroxy-2-methyl-10-phenyl-7-(phenylmethoxy)-5-(1,1,2,2-tetramethyl-1-silapropoxy)decan-4-one

Guidance literature:: 4-methyl-1-(1,1,2,2-tetramethyl-1-silapropoxy)pentan-2-one; With N,N-dimethyl-ethanamine; dicyclohexylboron chloride; In pentane; at 0 - 20 ℃;

(2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-phenyl-2-(phenylmethoxy)pentanal; In pentane; at -78 - -20 ℃; for 9h;

With phosphate buffer; dihydrogen peroxide; In methanol; water; at 20 ℃; for 1h; pH=7;
DOI:10.1021/ol051226f

Reference yield:

: 163089-34-7
N-methoxy-N-methyl-2-(1,1,2,2-tetramethyl-1-silapropoxy)acetamide

: 862423-78-7
(5R,6R,7S,8R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-6-hydroxy-2-methyl-10-phenyl-7-(phenylmethoxy)-5-(1,1,2,2-tetramethyl-1-silapropoxy)decan-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / tetrahydrofuran; diethyl ether / 1.5 h / 0 °C

2.1: dicyclohexylchloroborane; EtNMe₂ / pentane / 0 - 20 °C

2.2: pentane / 9 h / -78 - -20 °C

2.3: H₂O₂; phosphate buffer / methanol; H₂O / 1 h / 20 °C / pH 7

With N,N-dimethyl-ethanamine; dicyclohexylboron chloride; In tetrahydrofuran; diethyl ether; pentane; 2.2: aldol reaction;
DOI:10.1021/ol051226f

Reference yield:

: 862423-84-5
(2R,3R)-3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-N-methoxy-N-methyl-5-phenyl-2-(phenylmethoxy)pentamide

: 862423-78-7
(5R,6R,7S,8R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-6-hydroxy-2-methyl-10-phenyl-7-(phenylmethoxy)-5-(1,1,2,2-tetramethyl-1-silapropoxy)decan-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / DIBAL-H / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.1: dicyclohexylchloroborane; EtNMe₂ / pentane / 0 - 20 °C

2.2: pentane / 9 h / -78 - -20 °C

2.3: H₂O₂; phosphate buffer / methanol; H₂O / 1 h / 20 °C / pH 7

With N,N-dimethyl-ethanamine; dicyclohexylboron chloride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; pentane; 2.2: aldol reaction;
DOI:10.1021/ol051226f