3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,6-di-n-propylphenoxy)-butyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

Base Information

Chemical Name:3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,6-di-n-propylphenoxy)-butyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione
CAS No.:1031395-79-5
Molecular Formula:C₃₂H₄₀F₆N₂O₅
Molecular Weight:646.67
Hs Code.:

Synonyms:3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,6-di-n-propylphenoxy)-butyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

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Chemical Property of 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,6-di-n-propylphenoxy)-butyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

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Technology Process of 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,6-di-n-propylphenoxy)-butyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

There total 17 articles about 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,6-di-n-propylphenoxy)-butyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2,6-di-n-propyl-phenoxy)butyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

: 1031395-79-5
3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,6-di-n-propylphenoxy)-butyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2015.04.080

Reference yield:

: methyl 4-(benzyloxy)-3,5-di-n-propylbenzoate

: 1031395-79-5
3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,6-di-n-propylphenoxy)-butyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydroxide / water; ethanol / 2 h / Reflux

2: thionyl chloride / 2 h / 0 - 70 °C

3: tetramethylammonium fluoride / 1,2-dimethoxyethane / -78 - 20 °C / Inert atmosphere

4: sodium hydride / tetrahydrofuran / 0 - 20 °C

5: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 20 °C

8: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; thionyl chloride; palladium 10% on activated carbon; tetramethylammonium fluoride; hydrogen; sodium hydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.04.080

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1031395-79-5
3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,6-di-n-propylphenoxy)-butyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 15 steps

1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

2: N,N-dimethyl-aniline / 18 h / 210 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 50 °C

5: N,N-dimethyl-aniline / 18 h / 210 °C

6: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 20 °C / Molecular sieve

7: potassium carbonate / N,N-dimethyl-formamide / 2 h / 70 °C

8: sodium hydroxide / water; ethanol / 2 h / Reflux

9: thionyl chloride / 2 h / 0 - 70 °C

10: tetramethylammonium fluoride / 1,2-dimethoxyethane / -78 - 20 °C / Inert atmosphere

11: sodium hydride / tetrahydrofuran / 0 - 20 °C

12: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

13: potassium carbonate / N,N-dimethyl-formamide / 20 °C

14: potassium carbonate / N,N-dimethyl-formamide / 20 °C

15: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; thionyl chloride; palladium 10% on activated carbon; tetramethylammonium fluoride; hydrogen; sodium hydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; N,N-dimethyl-aniline; N,N-dimethyl-formamide; 2: |Claisen Rearrangement;
DOI:10.1016/j.bmcl.2015.04.080