(2S)-N-{(2R)-3-(N-benzylindol-3-yl)-2-[(dibenzylamino)methyl]propanoyl}camphorsultam

Base Information

Chemical Name:(2S)-N-{(2R)-3-(N-benzylindol-3-yl)-2-[(dibenzylamino)methyl]propanoyl}camphorsultam
CAS No.:943154-74-3
Molecular Formula:C₄₃H₄₇N₃O₃S
Molecular Weight:685.93
Hs Code.:

Synonyms:(2S)-N-{(2R)-3-(N-benzylindol-3-yl)-2-[(dibenzylamino)methyl]propanoyl}camphorsultam

Suppliers and Price of (2S)-N-{(2R)-3-(N-benzylindol-3-yl)-2-[(dibenzylamino)methyl]propanoyl}camphorsultam

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-N-{(2R)-3-(N-benzylindol-3-yl)-2-[(dibenzylamino)methyl]propanoyl}camphorsultam

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-N-{(2R)-3-(N-benzylindol-3-yl)-2-[(dibenzylamino)methyl]propanoyl}camphorsultam

There total 7 articles about (2S)-N-{(2R)-3-(N-benzylindol-3-yl)-2-[(dibenzylamino)methyl]propanoyl}camphorsultam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 943154-69-6
(2S)-N-[3-(N-benzylindol-3-yl)propanoyl]camphorsultam

: N,N-dibenzyliminium trifluoroacetate salt

: 943154-74-3
(2S)-N-{(2R)-3-(N-benzylindol-3-yl)-2-[(dibenzylamino)methyl]propanoyl}camphorsultam

Guidance literature:: (2S)-N-[3-(N-benzylindol-3-yl)propanoyl]camphorsultam; With trimethylsilyl trifluoromethanesulfonate; triethylamine; In dichloromethane; at 20 ℃; for 6h;

N,N-dibenzyliminium trifluoroacetate salt; In dichloromethane; for 0.25h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; Further stages.;
DOI:10.1002/ejoc.200600926

Reference yield:

: 830-96-6
Indole-3-propionic acid

: 943154-74-3
(2S)-N-{(2R)-3-(N-benzylindol-3-yl)-2-[(dibenzylamino)methyl]propanoyl}camphorsultam

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: 75 percent / dimethylformamide / 1 h

2.1: ClCO₂iBu; N-methylmorpholine / 1,2-dimethoxy-ethane / 0.25 h / -15 °C

2.2: 70 percent / NaH / 1,2-dimethoxy-ethane / 2 h / -15 - 20 °C

3.1: NEt₃; trimethylsilyl triflate / CH₂Cl₂ / 6 h / 20 °C

3.2: CH₂Cl₂ / 0.25 h

3.3: 88 percent / TBAF / CH₂Cl₂; tetrahydrofuran

With 4-methyl-morpholine; trimethylsilyl trifluoromethanesulfonate; sodium hydride; triethylamine; isobutyl chloroformate; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200600926

Reference yield:

: 141071-79-6
3-(1-Benzylindol-3-yl)propionic Acid

: 943154-74-3
(2S)-N-{(2R)-3-(N-benzylindol-3-yl)-2-[(dibenzylamino)methyl]propanoyl}camphorsultam

Guidance literature:: Multi-step reaction with 2 steps

1.1: ClCO₂iBu; N-methylmorpholine / 1,2-dimethoxy-ethane / 0.25 h / -15 °C

1.2: 70 percent / NaH / 1,2-dimethoxy-ethane / 2 h / -15 - 20 °C

2.1: NEt₃; trimethylsilyl triflate / CH₂Cl₂ / 6 h / 20 °C

2.2: CH₂Cl₂ / 0.25 h

2.3: 88 percent / TBAF / CH₂Cl₂; tetrahydrofuran

With 4-methyl-morpholine; trimethylsilyl trifluoromethanesulfonate; triethylamine; isobutyl chloroformate; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1002/ejoc.200600926