(R)-2-(N-tert-butyloxycarbonylaminomethyl)-3-N-benzylindol-3-ylpropanoic acid

Base Information

Chemical Name:(R)-2-(N-tert-butyloxycarbonylaminomethyl)-3-N-benzylindol-3-ylpropanoic acid
CAS No.:1050443-68-9
Molecular Formula:C₂₄H₂₈N₂O₄
Molecular Weight:408.497
Hs Code.:

Synonyms:

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Chemical Property of (R)-2-(N-tert-butyloxycarbonylaminomethyl)-3-N-benzylindol-3-ylpropanoic acid

Chemical Property:

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Technology Process of (R)-2-(N-tert-butyloxycarbonylaminomethyl)-3-N-benzylindol-3-ylpropanoic acid

There total 8 articles about (R)-2-(N-tert-butyloxycarbonylaminomethyl)-3-N-benzylindol-3-ylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₀N₂O₂

: 24424-99-5
di-tert-butyl dicarbonate

: 1050443-68-9
(R)-2-(N-tert-butyloxycarbonylaminomethyl)-3-N-benzylindol-3-ylpropanoic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; water;
DOI:10.1016/j.tetlet.2008.05.131

Reference yield:

: 943154-74-3
(2S)-N-{(2R)-3-(N-benzylindol-3-yl)-2-[(dibenzylamino)methyl]propanoyl}camphorsultam

: 1050443-68-9
(R)-2-(N-tert-butyloxycarbonylaminomethyl)-3-N-benzylindol-3-ylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran; methanol / 67 h / 20 °C / 3750.38 Torr

2: lithium hydroxide; water / acetonitrile / 20 °C

3: lithium hydroxide / 1,4-dioxane / 24 h / pH 9

With 20% palladium hydroxide-activated charcoal; water; hydrogen; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; acetonitrile;
DOI:10.1021/jm401419p

Reference yield:

: 141071-79-6
3-(1-Benzylindol-3-yl)propionic Acid

: 1050443-68-9
(R)-2-(N-tert-butyloxycarbonylaminomethyl)-3-N-benzylindol-3-ylpropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / mineral oil; 1,2-dimethoxyethane / 1 h / 20 °C / Inert atmosphere

1.2: 2 h / -15 - 20 °C / Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 6 h / 20 °C

3.1: dichloromethane / 0.25 h / 20 °C

3.2: 20 °C

4.1: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran; methanol / 67 h / 20 °C / 3750.38 Torr

5.1: lithium hydroxide; water / acetonitrile / 20 °C

6.1: lithium hydroxide / 1,4-dioxane / 24 h / pH 9

With trimethylsilyl trifluoromethanesulfonate; 20% palladium hydroxide-activated charcoal; water; hydrogen; sodium hydride; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; acetonitrile; mineral oil;
DOI:10.1021/jm401419p