2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetic acid

Base Information

Chemical Name:2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetic acid
CAS No.:1429340-13-5
Molecular Formula:C₃₅H₃₉FN₆O₈S
Molecular Weight:722.794
Hs Code.:

2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetic acid

Synonyms:2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetic acid

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Chemical Property of 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetic acid

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Technology Process of 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetic acid

There total 5 articles about 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1429340-33-9
ethyl 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetate

: 1429340-13-5
2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetic acid

Guidance literature:: With methanol; sodium hydroxide; at 20 ℃; for 24h;

Reference yield:

: 1187213-95-1
1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea

: 1429340-13-5
2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 1-methyl-pyrrolidin-2-one / 0.33 h / 20 °C

1.2: 72 h

2.1: N,N-dimethyl-formamide / 72 h / 20 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 6 h / 20 °C

4.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1 h / 20 °C

5.1: sodium hydroxide; methanol / 24 h / 20 °C

With hydrogenchloride; methanol; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1342837-20-0
tert-butyl 3-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)azetidine-1-carboxylate

: 1429340-13-5
2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 72 h / 20 °C

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 6 h / 20 °C

3: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1 h / 20 °C

4: sodium hydroxide; methanol / 24 h / 20 °C

With hydrogenchloride; methanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;