ethyl 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetate

Base Information

Chemical Name:ethyl 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetate
CAS No.:1429340-33-9
Molecular Formula:C₃₇H₄₃FN₆O₈S
Molecular Weight:750.848
Hs Code.:

ethyl 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetate

Synonyms:ethyl 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetate

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Chemical Property of ethyl 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetate

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Technology Process of ethyl 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetate

There total 4 articles about ethyl 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16024-58-1
2-[2-(2-methoxyethoxy)etoxy]acetic acid

: ethyl 2-(azetidin-3-yl((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)amino)acetate

: 1429340-33-9
ethyl 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; at 20 ℃; for 1h;

Reference yield:

: 1187213-95-1
1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea

: 1429340-33-9
ethyl 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 1-methyl-pyrrolidin-2-one / 0.33 h / 20 °C

1.2: 72 h

2.1: N,N-dimethyl-formamide / 72 h / 20 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 6 h / 20 °C

4.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1342837-20-0
tert-butyl 3-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)azetidine-1-carboxylate

: 1429340-33-9
ethyl 2-(((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)(1-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)azetidin-3-yl)amino)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 72 h / 20 °C

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 6 h / 20 °C

3: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;