methyl 4-((3-((3-((tert-butoxycarbonyl)amino)propyl)(methyl)amino)propyl)amino)-2-(3-(2,2,2-trifluoroacetyl)benzyl)-9H-pyrimido[4,5-b]indole-7-carboxylate

Base Information

Chemical Name:methyl 4-((3-((3-((tert-butoxycarbonyl)amino)propyl)(methyl)amino)propyl)amino)-2-(3-(2,2,2-trifluoroacetyl)benzyl)-9H-pyrimido[4,5-b]indole-7-carboxylate
CAS No.:1448724-54-6
Molecular Formula:C₃₃H₃₉F₃N₆O₅
Molecular Weight:656.705
Hs Code.:

methyl 4-((3-((3-((tert-butoxycarbonyl)amino)propyl)(methyl)amino)propyl)amino)-2-(3-(2,2,2-trifluoroacetyl)benzyl)-9H-pyrimido[4,5-b]indole-7-carboxylate

Synonyms:methyl 4-((3-((3-((tert-butoxycarbonyl)amino)propyl)(methyl)amino)propyl)amino)-2-(3-(2,2,2-trifluoroacetyl)benzyl)-9H-pyrimido[4,5-b]indole-7-carboxylate

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Chemical Property of methyl 4-((3-((3-((tert-butoxycarbonyl)amino)propyl)(methyl)amino)propyl)amino)-2-(3-(2,2,2-trifluoroacetyl)benzyl)-9H-pyrimido[4,5-b]indole-7-carboxylate

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Technology Process of methyl 4-((3-((3-((tert-butoxycarbonyl)amino)propyl)(methyl)amino)propyl)amino)-2-(3-(2,2,2-trifluoroacetyl)benzyl)-9H-pyrimido[4,5-b]indole-7-carboxylate

There total 10 articles about methyl 4-((3-((3-((tert-butoxycarbonyl)amino)propyl)(methyl)amino)propyl)amino)-2-(3-(2,2,2-trifluoroacetyl)benzyl)-9H-pyrimido[4,5-b]indole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1448724-53-5
methyl 4-((3-((3-((tert-butoxycarbonyl)amino)propyl)(methyl)amino)propyl)amino)-2-(3-(2,2,2-trifluoro-1-hydroxyethyl)benzyl)-9H-pyrimido[4,5-b]indole-7-carboxylate

: 1448724-54-6
methyl 4-((3-((3-((tert-butoxycarbonyl)amino)propyl)(methyl)amino)propyl)amino)-2-(3-(2,2,2-trifluoroacetyl)benzyl)-9H-pyrimido[4,5-b]indole-7-carboxylate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 40061-55-0
ethyl m-methylphenylacetate

: 1448724-54-6
methyl 4-((3-((3-((tert-butoxycarbonyl)amino)propyl)(methyl)amino)propyl)amino)-2-(3-(2,2,2-trifluoroacetyl)benzyl)-9H-pyrimido[4,5-b]indole-7-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / Reflux

2.1: 4-methylmorpholine N-oxide / 1,4-dioxane / 1.5 h / 100 °C

3.1: cesium fluoride / N,N-dimethyl-formamide / 1.5 h / 0 - 5 °C

3.2: 0.5 h / 0 - 5 °C

4.1: potassium carbonate / acetonitrile / 24 h / 75 - 80 °C

5.1: sodium methylate / methanol / 1 h / 140 °C / Microwave irradiation

5.2: 2 h / 20 °C

6.1: trichlorophosphate / 2 h / 90 °C

7.1: methanol / 0.5 h / 140 °C / Microwave irradiation

8.1: triethylamine / methanol; dichloromethane / 0.75 h / 20 °C

9.1: palladium 10% on activated carbon; hydrogen / methanol / 22 h / 20 °C

10.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

With N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; sodium methylate; potassium carbonate; Dess-Martin periodane; 4-methylmorpholine N-oxide; triethylamine; cesium fluoride; trichlorophosphate; dibenzoyl peroxide; In 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 140215-42-5
(3-bromomethylphenyl)acetic acid ethyl ester

: 1448724-54-6
methyl 4-((3-((3-((tert-butoxycarbonyl)amino)propyl)(methyl)amino)propyl)amino)-2-(3-(2,2,2-trifluoroacetyl)benzyl)-9H-pyrimido[4,5-b]indole-7-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 4-methylmorpholine N-oxide / 1,4-dioxane / 1.5 h / 100 °C

2.1: cesium fluoride / N,N-dimethyl-formamide / 1.5 h / 0 - 5 °C

2.2: 0.5 h / 0 - 5 °C

3.1: potassium carbonate / acetonitrile / 24 h / 75 - 80 °C

4.1: sodium methylate / methanol / 1 h / 140 °C / Microwave irradiation

4.2: 2 h / 20 °C

5.1: trichlorophosphate / 2 h / 90 °C

6.1: methanol / 0.5 h / 140 °C / Microwave irradiation

7.1: triethylamine / methanol; dichloromethane / 0.75 h / 20 °C

8.1: palladium 10% on activated carbon; hydrogen / methanol / 22 h / 20 °C

9.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium methylate; potassium carbonate; Dess-Martin periodane; 4-methylmorpholine N-oxide; triethylamine; cesium fluoride; trichlorophosphate; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;