(S)-tert-butyl 2-(3-(5-(3-aminophenyl)oxazol-2-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 2-(3-(5-(3-aminophenyl)oxazol-2-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate
CAS No.:1541243-62-2
Molecular Formula:C₂₅H₂₈N₄O₄
Molecular Weight:448.522
Hs Code.:

Synonyms:(S)-tert-butyl 2-(3-(5-(3-aminophenyl)oxazol-2-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-(3-(5-(3-aminophenyl)oxazol-2-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate

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Technology Process of (S)-tert-butyl 2-(3-(5-(3-aminophenyl)oxazol-2-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate

There total 4 articles about (S)-tert-butyl 2-(3-(5-(3-aminophenyl)oxazol-2-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541243-61-1
C₂₅H₂₆N₄O₆

: 1541243-62-2
(S)-tert-butyl 2-(3-(5-(3-aminophenyl)oxazol-2-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h; under 1034.32 Torr; Inert atmosphere;
DOI:10.1021/jm4016203

Reference yield:

: 1541243-60-0
(S)-tert-butyl 2-(3-(2-(3-nitrophenyl)-2-oxoethylcarbamoyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

: 1541243-62-2
(S)-tert-butyl 2-(3-(5-(3-aminophenyl)oxazol-2-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; triethylamine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

1.2: 16 h / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 1034.32 Torr / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; triphenylphosphine; In methanol; dichloromethane;
DOI:10.1021/jm4016203

Reference yield:

: 36765-84-1
α-amino-m-nitroacetophenone hydrochloride

: 1541243-62-2
(S)-tert-butyl 2-(3-(5-(3-aminophenyl)oxazol-2-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / Inert atmosphere

2.1: triphenylphosphine; triethylamine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

2.2: 16 h / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 1034.32 Torr / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm4016203