36765-84-1

Usage

Uses

Used in Scientific Research:
3-Nitrophenacylamine Hydrochloride is used as a reagent in various scientific research applications for its distinctive properties that facilitate specific organic reactions.
Used in Laboratory Experiments:
In laboratory settings, 3-Nitrophenacylamine Hydrochloride is used as a compound in experimental procedures, where its chemical characteristics contribute to the understanding and development of new chemical processes and products.
While there is no absolute evidence specifying its wide use in industries such as pharmaceuticals, agriculture, or cosmetics, the compound's potential applications in these fields could be explored further, given its unique properties and reactivity in organic reactions.

InChI:InChI=1/C8H8N2O3/c9-5-8(11)6-2-1-3-7(4-6)10(12)13/h1-4H,5,9H2/p+1

Upstream product

• 7478-10-6 1-(m-nitrophenyl)-3,5,7-triaza-1-azoniaadamantane bromide 
• 98-86-2 acetophenone 
• 121-89-1 3-Nitroacetophenone 
• 2227-64-7 3'-nitro-2-bromoacetophenone 

Downstream Products

• 137965-23-2 α-(dichloroacetamido)-m-nitroacetophenone 
• 1456532-28-7 2-amino-1-(3-nitrophenyl)ethan-1-one thiosemicarbazone 
• 1541243-60-0 (S)-tert-butyl 2-(3-(2-(3-nitrophenyl)-2-oxoethylcarbamoyl)phenylcarbamoyl)pyrrolidine-1-carboxylate 
• 1541243-65-5 (2S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-N-[3-(2-{3-[(2S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]pyrrolidine-2-amido]phenyl}-1,3-oxazol-5-yl)phenyl]pyrrolidine-2-carboxamide 
• 1541243-63-3 C₃₅H₄₃N₅O₇ 
• 1541243-62-2 (S)-tert-butyl 2-(3-(5-(3-aminophenyl)oxazol-2-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate 
• 1541243-61-1 C₂₅H₂₆N₄O₆ 
• 1350614-56-0 C₁₃H₁₆N₂O₅ 
• 859481-13-3 5‐(3‐nitrophenyl)‐1,3‐thiazole 
• 137965-27-6 2,2-Dichloro-N-[(4R,5R)-2,2-dimethyl-4-(3-nitro-phenyl)-[1,3]dioxan-5-yl]-acetamide 
• 137965-25-4 2-(dichloroacetamido)-2-(m-nitrobenzoyl)-1,3-propanediol 
• 137965-24-3 α-(dichloroacetamido)-β-hydroxy-m-nitropropiophenone 
• 138125-72-1 2-(dichloroacetamido)-1-(m-nitrophenyl)-1,3-propanediol 
• 90490-70-3 2-(2,5-Dimethyl-pyrrol-1-yl)-1-(3-nitro-phenyl)-ethanone 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates

The present work reports on the synthesis, biological assaying and docking studies of a series of 12 aryl thiosemicarbazones, which were planned to act over two main enzymes, cruzain and trypanothione reductase. These enzymes are used as targets of trypanocidal activity in Chagas disease control with a minimal mutagenic profile. Three p-nitroaromatic thiosemicarbazones showed high activity against Trypanosoma cruzi in in vitro assays (IC50 57 μM), and no mutagenic profile was observed in micronucleous tests. Although the in vitro inhibition test showed that 10-μM doses of eight compounds inhibited cruzain activity, no correlation was found between cruzain inhibition and trypanocidal activity.

Thiadizines

Novel heterocyclic compounds of the formula: STR1 wherein either X is --CR1 R2 -- and Y is oxygen, sulphur or --NR3, wherein R1, R2 and R3, which may be the same or different, each is hydrogen or alkyl of up to 4 carbon atoms; or X is oxygen, sulphur or --NH-- and Y is --CH2 --; wherein R4 and R5, which may be the same or different, each is hydrogen, cyano, nitro, amino or hydroxy, or alkylthio of up to 4 carbon atoms, or has various other meanings defined in claim 1, provided that R4 and R5 are not both hydrogen; or wherein R4 and R5 are joined together such that with the benzene ring A they form a benzheterocyclic ring as defined in claim 1; and therein the benzene ring A may optionally bear one or more further substituents; or a salt thereof where appropriate. These compounds possess cardiotonic properties, and some of them possess peripheral vasodilator properties, and they are useful for the treatment of acute or chronic heart failure. Representative of the compounds is N,N-dimethyl-p-(5,6-dihydro-5-oxo-4H-1,3,4-thiadiazin-2-yl)benzamide. Also disclosed are processes for the manufacture of the compounds and pharmaceutical compositions containing them.