1-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-3-methyl-urea trifluoroacetic acid

Base Information

Chemical Name:1-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-3-methyl-urea trifluoroacetic acid
CAS No.:1352873-00-7
Molecular Formula:C₂HF₃O₂*C₂₈H₂₄ClN₅O
Molecular Weight:596.008
Hs Code.:

Synonyms:1-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-3-methyl-urea trifluoroacetic acid

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Chemical Property of 1-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-3-methyl-urea trifluoroacetic acid

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Technology Process of 1-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-3-methyl-urea trifluoroacetic acid

There total 8 articles about 1-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-3-methyl-urea trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1352874-29-3
[1-(2'-amino-biphenyl-4-yl)-3-(2-chloro-benzyl)-1,3-dihydro-benzoimidazol-(2E)-ylidene]-carbamic acid tert-butyl ester

: 624-83-9
methyl isocyanate

: 76-05-1
trifluoroacetic acid

: 1352873-00-7
1-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-3-methyl-urea trifluoroacetic acid

Guidance literature:: [1-(2'-amino-biphenyl-4-yl)-3-(2-chloro-benzyl)-1,3-dihydro-benzoimidazol-(2E)-ylidene]-carbamic acid tert-butyl ester; methyl isocyanate; With pyridine; In dichloromethane; at 20 ℃; for 24h;

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1352873-00-7
1-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-3-methyl-urea trifluoroacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton

1.2: 0.25 h

2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C

3.1: water; acetonitrile / 18 h / 20 °C

4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation

5.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 44 h / 70 °C

6.1: sodium carbonate / 1,2-dimethoxyethane; water / 2.5 h / 90 °C

7.1: pyridine / dichloromethane / 24 h / 20 °C

7.2: 1 h / 20 °C

With pyridine; tin(II) chloride dihdyrate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1352873-00-7
1-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-3-methyl-urea trifluoroacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton

1.2: 0.25 h

2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C

3.1: water; acetonitrile / 18 h / 20 °C

4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation

5.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 44 h / 70 °C

6.1: sodium carbonate / 1,2-dimethoxyethane; water / 2.5 h / 90 °C

7.1: pyridine / dichloromethane / 24 h / 20 °C

7.2: 1 h / 20 °C

With pyridine; tin(II) chloride dihdyrate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;