2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethyl chloride

Base Information

Chemical Name:2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethyl chloride
CAS No.:187340-97-2
Molecular Formula:C₂₄H₃₂ClNO₂
Molecular Weight:401.977
Hs Code.:

Synonyms:2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethyl chloride

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Chemical Property of 2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethyl chloride

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Technology Process of 2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethyl chloride

There total 5 articles about 2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 187340-90-5
2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethanol

: 187340-97-2
2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethyl chloride

Guidance literature:: With thionyl chloride;
DOI:10.1016/S0960-894X(98)00159-0

Reference yield:

: 171270-07-8
(6-Benzyloxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methanol

: 187340-97-2
2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

2: 95 percent / 12 h / 120 °C

3: 96 percent / SOCl₂ / 2 h / 0 °C

With thionyl chloride; triethylamine; In dichloromethane; 1: mesylation / 2: Substitution / 3: Chlorination;
DOI:10.1021/jm9805541

Reference yield:

: 138564-72-4
(2RS)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl methanesulphonate

: 187340-97-2
2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 12 h / 120 °C

2: 96 percent / SOCl₂ / 2 h / 0 °C

With thionyl chloride; 1: Substitution / 2: Chlorination;
DOI:10.1021/jm9805541