4-[2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethoxy] nitrobenzene

Base Information

Chemical Name:4-[2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethoxy] nitrobenzene
CAS No.:187341-33-9
Molecular Formula:C₃₀H₃₆N₂O₅
Molecular Weight:504.626
Hs Code.:

Synonyms:4-[2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethoxy] nitrobenzene

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Chemical Property of 4-[2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethoxy] nitrobenzene

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Technology Process of 4-[2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethoxy] nitrobenzene

There total 5 articles about 4-[2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethoxy] nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 187340-97-2
2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethyl chloride

: 187341-33-9
4-[2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethoxy] nitrobenzene

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;
DOI:10.1021/jm9805541

Reference yield:

: 187340-90-5
2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethanol

: 187341-33-9
4-[2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethoxy] nitrobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / SOCl₂ / 2 h / 0 °C

2: 90 percent / K₂CO₃ / dimethylformamide / 4 h / 80 °C

With thionyl chloride; potassium carbonate; In N,N-dimethyl-formamide; 1: Chlorination / 2: Alkylation;
DOI:10.1021/jm9805541

Reference yield:

: 138564-72-4
(2RS)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl methanesulphonate

: 187341-33-9
4-[2-[N-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl)-N-methylamino]ethoxy] nitrobenzene

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / 12 h / 120 °C

2: 96 percent / SOCl₂ / 2 h / 0 °C

3: 90 percent / K₂CO₃ / dimethylformamide / 4 h / 80 °C

With thionyl chloride; potassium carbonate; In N,N-dimethyl-formamide; 1: Substitution / 2: Chlorination / 3: Alkylation;
DOI:10.1021/jm9805541