2-(tert-butylsulfonyl)-6-tosyl-2,6-diazaspiro[3.3]heptane-1-carboxylic acid

Base Information

Chemical Name:2-(tert-butylsulfonyl)-6-tosyl-2,6-diazaspiro[3.3]heptane-1-carboxylic acid
CAS No.:1349199-58-1
Molecular Formula:C₁₇H₂₄N₂O₆S₂
Molecular Weight:416.519
Hs Code.:

Synonyms:2-(tert-butylsulfonyl)-6-tosyl-2,6-diazaspiro[3.3]heptane-1-carboxylic acid

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Chemical Property of 2-(tert-butylsulfonyl)-6-tosyl-2,6-diazaspiro[3.3]heptane-1-carboxylic acid

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Technology Process of 2-(tert-butylsulfonyl)-6-tosyl-2,6-diazaspiro[3.3]heptane-1-carboxylic acid

There total 3 articles about 2-(tert-butylsulfonyl)-6-tosyl-2,6-diazaspiro[3.3]heptane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1349199-57-0
(R)-2-(tert-butylsulfinyl)-1-(furan-2-yl)-6-tosyl-2,6-diazaspiro[3.3]heptane

: 1349199-58-1
2-(tert-butylsulfonyl)-6-tosyl-2,6-diazaspiro[3.3]heptane-1-carboxylic acid

Guidance literature:: With sodium periodate; ruthenium(III) trichloride hydrate; water; In dichloromethane; acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/ol2028459

Reference yield:

: 1233143-50-4
3-(bromomethyl)-1-tosylazetidine-3-carbaldehyde

: 1349199-58-1
2-(tert-butylsulfonyl)-6-tosyl-2,6-diazaspiro[3.3]heptane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.08 h / -78 - -60 °C / Inert atmosphere

2.2: 0.33 h / -78 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.1: sodium periodate; ruthenium(III) trichloride hydrate; water / dichloromethane; acetonitrile / 1 h / 20 °C

With titanium(IV) tetraethanolate; sodium periodate; n-butyllithium; ruthenium(III) trichloride hydrate; potassium tert-butylate; water; In tetrahydrofuran; hexanes; dichloromethane; acetonitrile;
DOI:10.1021/ol2028459

Reference yield:

: 1349199-55-8
C₁₆H₂₃BrN₂O₃S₂

: 1349199-58-1
2-(tert-butylsulfonyl)-6-tosyl-2,6-diazaspiro[3.3]heptane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1.08 h / -78 - -60 °C / Inert atmosphere

1.2: 0.33 h / -78 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.1: sodium periodate; ruthenium(III) trichloride hydrate; water / dichloromethane; acetonitrile / 1 h / 20 °C

With sodium periodate; n-butyllithium; ruthenium(III) trichloride hydrate; potassium tert-butylate; water; In tetrahydrofuran; hexanes; dichloromethane; acetonitrile;
DOI:10.1021/ol2028459