(R)-2-(tert-butylsulfinyl)-1-(furan-2-yl)-6-tosyl-2,6-diazaspiro[3.3]heptane

Base Information

Chemical Name:(R)-2-(tert-butylsulfinyl)-1-(furan-2-yl)-6-tosyl-2,6-diazaspiro[3.3]heptane
CAS No.:1349199-57-0
Molecular Formula:C₂₀H₂₆N₂O₄S₂
Molecular Weight:422.569
Hs Code.:

Synonyms:(R)-2-(tert-butylsulfinyl)-1-(furan-2-yl)-6-tosyl-2,6-diazaspiro[3.3]heptane

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Chemical Property of (R)-2-(tert-butylsulfinyl)-1-(furan-2-yl)-6-tosyl-2,6-diazaspiro[3.3]heptane

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Technology Process of (R)-2-(tert-butylsulfinyl)-1-(furan-2-yl)-6-tosyl-2,6-diazaspiro[3.3]heptane

There total 3 articles about (R)-2-(tert-butylsulfinyl)-1-(furan-2-yl)-6-tosyl-2,6-diazaspiro[3.3]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1349199-56-9
(R)-N-((3-(bromomethyl)-1-tosylazetidin-3-yl)(furan-2-yl)methyl)-2-methylpropane-2-sulfinamide

: 1349199-57-0
(R)-2-(tert-butylsulfinyl)-1-(furan-2-yl)-6-tosyl-2,6-diazaspiro[3.3]heptane

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ol2028459

Reference yield:

: 1349199-55-8
C₁₆H₂₃BrN₂O₃S₂

: 1349199-57-0
(R)-2-(tert-butylsulfinyl)-1-(furan-2-yl)-6-tosyl-2,6-diazaspiro[3.3]heptane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1.08 h / -78 - -60 °C / Inert atmosphere

1.2: 0.33 h / -78 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; hexanes;
DOI:10.1021/ol2028459

Reference yield:

: 1233143-50-4
3-(bromomethyl)-1-tosylazetidine-3-carbaldehyde

: 1349199-57-0
(R)-2-(tert-butylsulfinyl)-1-(furan-2-yl)-6-tosyl-2,6-diazaspiro[3.3]heptane

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.08 h / -78 - -60 °C / Inert atmosphere

2.2: 0.33 h / -78 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

With titanium(IV) tetraethanolate; n-butyllithium; potassium tert-butylate; In tetrahydrofuran; hexanes;
DOI:10.1021/ol2028459