(2R,3R,11R,12R)-3,12-Bis-phenylcarbamoyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid

Base Information

• Chemical Name: (2R,3R,11R,12R)-3,12-Bis-phenylcarbamoyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid
• CAS No.: 76798-13-5
• Molecular Formula: C₂₈H₃₄N₂O₁₂
• Molecular Weight: 590.584
• Mol file: 76798-13-5.mol

Synonyms:(2R,3R,11R,12R)-3,12-Bis-phenylcarbamoyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid

Chemical Property of (2R,3R,11R,12R)-3,12-Bis-phenylcarbamoyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R,11R,12R)-3,12-Bis-phenylcarbamoyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid

There total 2 articles about (2R,3R,11R,12R)-3,12-Bis-phenylcarbamoyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3aS,10aS,13aS,20aS)-Dodecahydro-2,4,7,10,12,14,17,20-octaoxa-dicyclopenta[a,j]cyclooctadecene-1,3,11,13-tetraone (76777-45-2) + aniline (62-53-3) → (2S,3S,11S,12S)-3,12-Bis-phenylcarbamoyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid (76798-13-5,119719-59-4) + (2S,3S,11S,12S)-3,11-Bis-phenylcarbamoyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,12-dicarboxylic acid (76777-39-4)

Guidance literature:

In dichloromethane; Ambient temperature;

DOI:10.1021/ja00393a050

Reference yield:

dianhydride [18]-crown-6-R,R-tartaric acid (76777-45-2) + aniline (62-53-3) → (2R,3R,11R,12R)-3,12-Bis-phenylcarbamoyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid (76798-13-5)

Guidance literature:

With triethylamine; Yield given;

DOI:10.1016/S0040-4039(00)61883-X

Reference yield: 81.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (2R,3R,11R,12R)-3,12-Bis-phenylcarbamoyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid (76798-13-5) → (2R,3R,11R,12R)-3,12-Bis-phenylcarbamoyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid dimethyl ester (97462-83-4)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 ℃;

upstream raw materials:

dianhydride [18]-crown-6-R,R-tartaric acid

aniline

(3aS,10aS,13aS,20aS)-Dodecahydro-2,4,7,10,12,14,17,20-octaoxa-dicyclopenta[a,j]cyclooctadecene-1,3,11,13-tetraone

Downstream raw materials:

(2R,3R,11R,12R)-3,12-Bis-phenylcarbamoyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid dimethyl ester

syn-(2R,3R,11R,12R)-(+)-2,11-bis(4',4'-dimethyl-2-oxazolidine)-3,12-dicarboxanilide-1,4,7,10,13,16-hexaoxacyclooctadecane

syn-(2R,3R,11R,12R)-(+)-2,11-bis(4',4'-dimethyl-2-oxazoline-2-yl)-3,12-dicarboxanilide-1,4,7,10,13,16-hexaoxacyclooctadecane

C₃₀H₃₆N₄O₁₄