(R)-1-((2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-but-3-en-1-ol

Base Information

Chemical Name:(R)-1-((2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-but-3-en-1-ol
CAS No.:370886-70-7
Molecular Formula:C₃₃H₅₀O₅Si
Molecular Weight:554.842
Hs Code.:

Synonyms:(R)-1-((2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-but-3-en-1-ol

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Chemical Property of (R)-1-((2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-but-3-en-1-ol

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Technology Process of (R)-1-((2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-but-3-en-1-ol

There total 11 articles about (R)-1-((2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-but-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 370886-70-7
(R)-1-((2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-but-3-en-1-ol

Guidance literature:: Multi-step reaction with 10 steps

1: 2,6-lutidine / CH₂Cl₂ / 0 °C

2: CSA / methanol; CH₂Cl₂ / 20 °C

3: 100 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

4: TPAP; NMO; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

5: L-selectride / tetrahydrofuran / -78 °C

6: CSA / methanol; CH₂Cl₂ / 20 °C

7: NaH / dimethylformamide / 0 - 20 °C

8: OsO₄; NMO / acetone; H₂O / 20 °C

9: NaIO₄ / tetrahydrofuran; H₂O / 20 °C

10: MgBr₂*OEt₂ / CH₂Cl₂ / -78 - 20 °C

With 2,6-dimethylpyridine; dmap; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; camphor-10-sulfonic acid; L-Selectride; sodium hydride; triethylamine; magnesium bromide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(01)01067-X

Reference yield:

: 24850-33-7
allyltributylstanane

: 370886-85-4
(2R,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-carbaldehyde

: 370886-70-7
(R)-1-((2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-but-3-en-1-ol

: (S)-1-((2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-but-3-en-1-ol

Guidance literature:: With magnesium bromide; In dichloromethane; at -78 - 20 ℃;
DOI:10.1016/S0040-4039(01)01067-X

Reference yield:

: (2R,4aR,6S,7R)-2-Phenyl-6-vinyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

: 370886-70-7
(R)-1-((2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-but-3-en-1-ol

Guidance literature:: Multi-step reaction with 10 steps

1: 2,6-lutidine / CH₂Cl₂ / 0 °C

2: CSA / methanol; CH₂Cl₂ / 20 °C

3: 100 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

4: TPAP; NMO; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

5: L-selectride / tetrahydrofuran / -78 °C

6: CSA / methanol; CH₂Cl₂ / 20 °C

7: NaH / dimethylformamide / 0 - 20 °C

8: OsO₄; NMO / acetone; H₂O / 20 °C

9: NaIO₄ / tetrahydrofuran; H₂O / 20 °C

10: MgBr₂*OEt₂ / CH₂Cl₂ / -78 - 20 °C

With 2,6-dimethylpyridine; dmap; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; camphor-10-sulfonic acid; L-Selectride; sodium hydride; triethylamine; magnesium bromide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(01)01067-X