Vindesine sulfate

Base Information

• Chemical Name: Vindesine sulfate
• CAS No.: 59917-39-4
• Molecular Formula: C43H55N5O7^.H2SO4
• Molecular Weight: 852.018
• Hs Code.: 2942000000
• European Community (EC) Number: 261-984-7
• DSSTox Substance ID: DTXSID0049074
• NCI Thesaurus Code: C935
• Metabolomics Workbench ID: 54529
• ChEMBL ID: CHEMBL2105882
• Mol file: 59917-39-4.mol

Synonyms:Compound 112531;Desacetylvinblastine Amide;Eldisine;Enison;NSC 245467;NSC-245467;NSC245467;Sulfate, Vindesine;Vindesin;Vindesine;Vindesine Sulfate

Chemical Property of Vindesine sulfate

Chemical Property:

• Appearance/Colour: Amorphous solid
• Melting Point: >250oC
• PSA: 247.80000
• Density: 1.41 g/cm3
• LogP: 3.80150
• Storage Temp.: 2-8°C
• Solubility.: deionized water: ≥50mg/mL
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 7
• Exact Mass: 851.37752882
• Heavy Atom Count: 60
• Complexity: 1650

Purity/Quality:

99% ^*data from raw suppliers

Vindesine sulfate salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 40
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O.OS(=O)(=O)O
• Isomeric SMILES: CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O.OS(=O)(=O)O
• Recent ClinicalTrials: Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents
• Recent EU Clinical Trials: A multicentre, randomized trial in adults with de novo Philadelphia-Chromosome positive acute lymphoblastic leukemia to assess the efficacy of ponatinib versus imatinib in combination with low-intensity chemotherapy, to compare end of therapy with indication for SCT versus TKI, blinatumomab and chemotherapy in optimal responders and to evaluate blinatumomab in suboptimal responders (GMALL-EVOLVE)
• Uses: anticancer Synthetic derivative of the dimeric Catharanthus alkaloid vinblastine. Antineoplastic Vindesine Sulfate Salt is a synthetic derivative of the dimeric Catharanthus alkaloid vinblastine. Antineoplastic.

Technology Process of Vindesine sulfate

There total 1 articles about Vindesine sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-vincaleukoblastine, sulfate (1:1) (salt) (59917-39-4)

Guidance literature:

aus Vinblastin, NH3 fl./Δ (Druck);