CAS No.59917-39-4,Vindesine sulfate Suppliers

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Basic Information

Molecular Structure:
CAS No.:	59917-39-4
Name:	Vindesine sulfate

Formula:	C₄₃H₅₅N₅O₇^.H₂SO₄
Molecular Weight:	852.018
Synonyms:	Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1) (salt);4-Desacetilvinblastina-C-3-carboxamida sulfato [Spanish];Fildesin (TN);Vindesine sulfate salt;Vindesine sulfate [USAN:JAN];Vindesine sulfate (JAN/USAN);Vindesina sulfato [Spanish];Fildesin;Desacetylvinblastine amide sulfate, compd. with mannitol;Lilly 99094;Desacetylvinblastine amide sulfate compound with mannitol;DAVA;3-Carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate (1:1) (salt);Eldesine;3-Carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate;Vincaleukoblastine, 3-(aminocarbonyl)-O(4)-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1) (salt), mixt. with D-mannitol;Eldisine;23-Amino-O(sup 4)-deacetyl-23-demethoxyvincaleukoblastine sulfate;Vincaleukoblastine, 3-(aminocarbonyl)-O(sup 4)-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1) (salt);Vincaleukoblastine,3-(aminocarbonyl)-O4- deacetyl-3-de(methoxycarbonyl)-,sulfate (1:1) (salt);Desacetylvinblastine amide sulfate;Vincaleukoblastine, 23-amino-O(sup 4)-deacetyl-23-demethoxy-, sulfate;
EINECS:	261-984-7
Density:	1.41 g/cm3
Melting Point:	>250oC
Appearance:	Amorphous solid
Hazard Symbols:	Xn
Risk Codes:	40
Safety:	26-36
PSA:	247.80000
LogP:	3.80150

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Chemistry

The molecular structure of Vindesine sulfate (59917-39-4) as follow:

EINECS: 261-984-7
Molecular formula: C₄₃H₅₇N₅O₁₁S
Formula weight: 852
Synonyms: 23-amino-o(sup4)-deacetyl-23-demethoxyvincaleukoblastine sulfate ; 23-amino-o(sup4)-deacetyl-23-demethoxy-vincaleukoblastin sulfate ; 3-carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate ; 4-desacetilvinblastina-c-3-carboxamida sulfato ; desacetylvinblastine amide sulfate ; eldesine ; eldisine
Melting point: >250 ℃
Appearance: Amorphous solid
The product categories about vindesine sulfate (59917-39-4) belong to intermediates & fine chemicals; pharmaceuticals.

Uses

Vindesine sulfate (59917-39-4) is a synthetic derivative of the dimeric Catharanthus alkaloid vinblastine. It is used as a kind of anticancer drugs and the extensive usage is applied in antineoplastic combined chemotherapy protocols.

Toxicity Data With Reference

mouse	LD₅₀	intraperitoneal	3500ug/kg (3.5mg/kg)	BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.
mouse	LD₅₀	intravenous	6300ug/kg (6.3mg/kg)		Journal of Toxicology and Environmental Health. Vol. 1, Pg. 843, 1976.
mouse	LD₅₀	subcutaneous	6800ug/kg (6.8mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.
rat	LD₅₀	intraperitoneal	1050ug/kg (1.05mg/kg)	BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.
rat	LD₅₀	intravenous	1920ug/kg (1.92mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: NORMOCYTIC ANEMIA KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.
rat	LD₅₀	subcutaneous	1790ug/kg (1.79mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.

Safety Profile

Poison by subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of SO_x and NO_x.

Hazard codes: Xn Harmful
Risk statements: 40 Limited evidence of a carcinogenic effect.
Safety statements: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
36 Wear suitable protective clothing.

Specification

Vindesine sulfate (59917-39-4) should be stored at 2-8 ℃. As an anticancer drug, the major side effects of it are myelosuppression and neurotoxicity.