N-((1-amino-8-fluoroisoquinolin-4-yl)methyl)-N-(3-chlorophenyl)-4-methylthiazole-5-carboxamide

Base Information

Chemical Name:N-((1-amino-8-fluoroisoquinolin-4-yl)methyl)-N-(3-chlorophenyl)-4-methylthiazole-5-carboxamide
CAS No.:1050203-14-9
Molecular Formula:C₂₁H₁₆ClFN₄OS
Molecular Weight:426.902
Hs Code.:

Synonyms:N-((1-amino-8-fluoroisoquinolin-4-yl)methyl)-N-(3-chlorophenyl)-4-methylthiazole-5-carboxamide

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Chemical Property of N-((1-amino-8-fluoroisoquinolin-4-yl)methyl)-N-(3-chlorophenyl)-4-methylthiazole-5-carboxamide

Chemical Property:

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Technology Process of N-((1-amino-8-fluoroisoquinolin-4-yl)methyl)-N-(3-chlorophenyl)-4-methylthiazole-5-carboxamide

There total 8 articles about N-((1-amino-8-fluoroisoquinolin-4-yl)methyl)-N-(3-chlorophenyl)-4-methylthiazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1050203-49-0
N-((1-chloro-8-fluoroisoquinolin-4-yl)methyl)-N-(3-chlorophenyl)-4-methylthiazole-5-carboxamide

: 1050203-14-9
N-((1-amino-8-fluoroisoquinolin-4-yl)methyl)-N-(3-chlorophenyl)-4-methylthiazole-5-carboxamide

Guidance literature:: With ammonia; formamide; In ethanol; water; at 100 ℃; for 1h; Sealed tube;

Reference yield:

: 1050203-43-4
N-allyl-N-benzyl-2-fluoro-6-iodobenzamide

: 1050203-14-9
N-((1-amino-8-fluoroisoquinolin-4-yl)methyl)-N-(3-chlorophenyl)-4-methylthiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-cyclohexyl-cyclohexanamine / palladium diacetate; triphenylphosphine / ISOPROPYLAMIDE / 18 h / 100 °C

2.1: sulfuric acid; water / 2.5 h / 150 °C

3.1: phosphorus tribromide; phosphorus(V) oxybromide / 4 h / 120 °C

3.2: pH 9

4.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 80 °C

5.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 40 °C

6.1: N,N-dimethyl-formamide / 1 h / 0 °C

7.1: ammonia; formamide / ethanol; water / 1 h / 100 °C / Sealed tube

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; ammonia; water; phosphorus tribromide; sodium carbonate; formamide; N-cyclohexyl-cyclohexanamine; phosphorus(V) oxybromide; palladium diacetate; triphenylphosphine; In tetrachloromethane; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;

Reference yield:

: 372-19-0
meta-fluoroaniline

: 1050203-14-9
N-((1-amino-8-fluoroisoquinolin-4-yl)methyl)-N-(3-chlorophenyl)-4-methylthiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid; sodium nitrite / water / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / diethyl ether / 1 h / -70 °C

2.2: 1 h / -50 °C

2.3: pH 1

3.1: thionyl chloride / 0.25 h / 80 °C

3.2: 2 h / 5 - 20 °C

4.1: N-cyclohexyl-cyclohexanamine / palladium diacetate; triphenylphosphine / ISOPROPYLAMIDE / 18 h / 100 °C

5.1: sulfuric acid; water / 2.5 h / 150 °C

6.1: phosphorus tribromide; phosphorus(V) oxybromide / 4 h / 120 °C

6.2: pH 9

7.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 80 °C

8.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 40 °C

9.1: N,N-dimethyl-formamide / 1 h / 0 °C

10.1: ammonia; formamide / ethanol; water / 1 h / 100 °C / Sealed tube

With N-Bromosuccinimide; n-butyllithium; thionyl chloride; 2,2'-azobis(isobutyronitrile); sulfuric acid; ammonia; water; phosphorus tribromide; sodium carbonate; formamide; N-ethyl-N,N-diisopropylamine; N-cyclohexyl-cyclohexanamine; sodium nitrite; phosphorus(V) oxybromide; palladium diacetate; triphenylphosphine; In tetrachloromethane; diethyl ether; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;