6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(4-chlorophenoxy)-2'-deoxyguanosine

Base Information

Chemical Name:6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(4-chlorophenoxy)-2'-deoxyguanosine
CAS No.:1312103-91-5
Molecular Formula:C₃₅H₅₀ClN₅O₅Si₂
Molecular Weight:712.437
Hs Code.:

Synonyms:6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(4-chlorophenoxy)-2'-deoxyguanosine

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Chemical Property of 6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(4-chlorophenoxy)-2'-deoxyguanosine

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Technology Process of 6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(4-chlorophenoxy)-2'-deoxyguanosine

There total 1 articles about 6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(4-chlorophenoxy)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 106-48-9,82344-39-6
4-chloro-phenol

: 479408-22-5
O⁶-benzyl-8-bromo-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 1312103-91-5
6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(4-chlorophenoxy)-2'-deoxyguanosine

Guidance literature:: With potassium phosphate; In xylenes; at 130 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201100013

Reference yield:

: 1312103-91-5
6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(4-chlorophenoxy)-2'-deoxyguanosine

: C₂₃H₂₂ClN₅O₅

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1002/ejoc.201100013

Reference yield:

: 1312103-91-5
6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(4-chlorophenoxy)-2'-deoxyguanosine

: 1312103-99-3
8-(4-chlorophenoxy)-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

2: 10% palladium on carbon; hydrogen / methanol

With 10% palladium on carbon; tetrabutyl ammonium fluoride; hydrogen; In tetrahydrofuran; methanol;
DOI:10.1002/ejoc.201100013