479408-22-5

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 13389-03-2 8-bromo-2'-deoxyguanosine 
• 100-51-6 benzyl alcohol 
• 479408-21-4 3',5'-O,O'-bis(tert-butyldimethylsilyl)-8-bromo-2'-deoxyguanosine 

Downstream Products

• 479408-30-5 8-(N-2-amino-fluorene)-O⁶-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 1068435-04-0 O₆-benzyl-8N-(4-methylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 1068435-06-2 O₆-benzyl-8N-(3,5-dimethylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 1068435-03-9 O₆-benzyl-8N-(phenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 1068435-05-1 C₃₆H₅₁N₇O₄Si₂ 
• 1312103-93-7 6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(2,3,4,5,6-pentachlorophenoxy)-2'-deoxyguanosine 
• 1312103-89-1 6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(4-methylphenoxy)-2'-deoxyguanosine 
• 1312103-88-0 6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(2-methylphenoxy)-2'-deoxyguanosine 
• 1312103-91-5 6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(4-chlorophenoxy)-2'-deoxyguanosine 
• 1312103-90-4 6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(4-methoxyphenoxy)-2'-deoxyguanosine 
• 1312103-92-6 6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-(2,4,6-trichlorophenoxy)-2'-deoxyguanosine 
• 1312103-95-9 8-phenoxy-2′-deoxyguanosine 
• 1312103-96-0 8-(2-methylphenoxy)-2'-deoxyguanosine 
• 1312103-87-9 6-O-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-8-phenoxy-2'-deoxyguanosine 

Relevant academic research and scientific papers

Synthesis of oligonucleotides containing 2′-deoxyguanosine adducts of nitropyrenes

Two different approaches to synthesize oligonucleotides containing the 2′-deoxyguanosine adducts formed by nitropyrenes are described. A direct reaction of an unmodified oligonucleotide with an activated nitropyrene derivative is a convenient biomimetic approach for generating the major adducts in DNA. A total synthetic approach, by contrast, involves several synthetic steps, including Buchwald-Hartwig Pd-catalyzed coupling, but can be used for incorporating both the major and minor adducts in DNA in high yield. Copyright Taylor & Francis Group, LLC.

Synthesis of DNA-oligonucleotides damaged by arylamine-modified 2′-deoxyguanosine

C8-Arylamine-dG adducts bearing a labile N-formamidine group at the exocyclic amino function were converted into their corresponding 5′-O-DMTr-3′-O-phosphoramidite-C8-arylamine-dG derivatives. These compounds were used for the automated synthesis of site-

Synthesis of oligonucleotides bearing an arylamine modification in the C8-position of 2′-deoxyguanosine

C8-Arylamine-dG adducts were converted into their corresponding 5′-0-DMTr-3′-0-phosphoramidite-C8-arylamine-dG derivatives. These compounds were used for the automated synthesis of site-specifically modified oligonucleotides. The oligonucleotides were stu

Preparation of C8-amine and acetylamine adducts of 2′-deoxyguanosine suitably protected for DNA synthesis

(Equation presented) C8-Amine and acetylamine adducts of 2′-deoxyguanosine were synthesized. Our approach provides solutions for the coupling of aromatic amines to a protected 8-bromo-2′-deoxyguanosine derivative, for the selective acetylation of the coup

Highly efficient synthesis of a phosphoramidite building block of C8-deoxyguanosine adducts of aromatic amines

The synthesis of 5′-O-DMTr-3′-O-phosphoramidite-C8-arylamine-dG adducts 11 and 12 is described. The compounds are potential building blocks for the automated synthesis of site-specifically modified oligonucleotides. The C8-adducts were synthesized by a pa