(R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-hept-6-enoic acid

Base Information

Chemical Name:(R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-hept-6-enoic acid
CAS No.:123382-13-8
Molecular Formula:C₂₈H₄₇NO₅Si
Molecular Weight:505.77
Hs Code.:

Synonyms:(R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-hept-6-enoic acid

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Chemical Property of (R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-hept-6-enoic acid

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Technology Process of (R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-hept-6-enoic acid

There total 1 articles about (R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-hept-6-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104293-46-1
[1-((2R,4R)-5-Oxo-4-pent-4-enyl-tetrahydro-furan-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 123382-13-8
(R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-hept-6-enoic acid

Guidance literature:: With 1H-imidazole; lithium hydroxide; Multistep reaction; 1.) dioxane, water, RT, overnight, 2.) DMF, 3 days;
DOI:10.1021/jm00163a059

Reference yield:

: 118233-41-3
(4S,5S)-5-Amino-6-cyclohexyl-4-hydroxy-2-methylene-hexanoic acid isobutyl-amide; hydrochloride

: 123382-13-8
(R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-hept-6-enoic acid

: 123411-33-6
[(1S,2R,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-((1S,2S)-1-cyclohexylmethyl-2-hydroxy-4-isobutylcarbamoyl-pent-4-enylcarbamoyl)-non-8-enyl]-carbamic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at -23 ℃; for 2h; Yield given;
DOI:10.1021/jm00163a059

Reference yield:

: 122621-77-6
(2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

: 123382-13-8
(R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-hept-6-enoic acid

: [(1S,2R,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-6-methyl-heptyl]-carbamic acid tert-butyl ester

Guidance literature:: With 1H-imidazole; lithium hydroxide; Multistep reaction; 1.) dioxane, water, RT, overnight, 2.) DMF, 3 days;
DOI:10.1021/jm00163a059