Chemical Property of Brazilin
Chemical Property:
- Vapor Pressure:3.44E-13mmHg at 25°C
- Melting Point:156-157oC
- Refractive Index:1.774
- Boiling Point:555.8 °C at 760 mmHg
- Flash Point:289.9 °C
- PSA：90.15000
- Density:1.604 g/cm3
- LogP:1.61490
- XLogP3:1.5
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:0
- Exact Mass:286.08412354
- Heavy Atom Count:21
- Complexity:416
- Purity/Quality:
-
≥98% *data from raw suppliers
Brazilin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1C2=CC(=C(C=C2C3C1(COC4=C3C=CC(=C4)O)O)O)O
- Isomeric SMILES:C1C2=CC(=C(C=C2[C@H]3[C@@]1(COC4=C3C=CC(=C4)O)O)O)O
-
Description
Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties. Brazilin inhibits Aβ (1-42) fibrillogenesis (IC50 = 1.5 μM) more potently than (-)-epigallocatechin gallate , cucurmin , and resveratrol (Item Nos. 10004235 | 70675). It also prevents remodeling of mature Aβ (1-42) fibrils. Brazilin inhibits the production of cytokines, including PGE2 and TNF-α (IC50s = 12.6 and 87.2 μM). It is effective against Gram-positive and Gram-negative bacteria with MICs ranging from 31.3 to 250 μg/ml. In addition, brazilin inhibits osteoclast differentiation mediated by RANKL and is protective against LPS-induced osteoporosis in mice at a dose of 100 mg/kg.
-
Uses
Brazilin is a hair dyeing composition that comprises a natural dye and fatty amine. inhibits platelet aggregation, PLA2, PKC, protein phosphatase, insulin receptor kinase, nitric oxide synthase, antineoplastic Chiefly as a dye. Has also been recommended as indicator in acid-base titrations; acids = yellow, alkalies = carmine-red.
