4-(3,5-difluoro-4-trifluoromethanesulfinyl-phenyl)-4'-propyl-bicyclohexyl

Base Information

• Chemical Name: 4-(3,5-difluoro-4-trifluoromethanesulfinyl-phenyl)-4'-propyl-bicyclohexyl
• CAS No.: 851341-11-2
• Molecular Formula: C₂₂H₂₉F₅OS
• Molecular Weight: 436.53
• Mol file: 851341-11-2.mol

Synonyms:4-(3,5-difluoro-4-trifluoromethanesulfinyl-phenyl)-4'-propyl-bicyclohexyl

Chemical Property of 4-(3,5-difluoro-4-trifluoromethanesulfinyl-phenyl)-4'-propyl-bicyclohexyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,5-difluoro-4-trifluoromethanesulfinyl-phenyl)-4'-propyl-bicyclohexyl

There total 3 articles about 4-(3,5-difluoro-4-trifluoromethanesulfinyl-phenyl)-4'-propyl-bicyclohexyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

4-(3,5-difluoro-4-trifluoromethylsulfanyl-phenyl)-4'-propyl-bicyclohexyl (851341-10-1) → 4-(3,5-difluoro-4-trifluoromethanesulfinyl-phenyl)-4'-propyl-bicyclohexyl (851341-11-2) + 4-(3,5-difluoro-4-trifluoromethanesulfonyl-phenyl)-4'-propyl-bicyclohexyl

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1002/ejoc.200400702

Reference yield:

2,6-difluoro-4-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)benzene (138074-21-2) → 4-(3,5-difluoro-4-trifluoromethanesulfinyl-phenyl)-4'-propyl-bicyclohexyl (851341-11-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran / -70 °C

1.2: 78 percent / I₂ / tetrahydrofuran / -40 °C

2.1: 56 percent / 1-methyl-pyrrolidin-2-one / 18 h / 120 - 150 °C

3.1: 28 percent / MCPBA / CH₂Cl₂ / 72 h / 20 °C

With n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;

DOI:10.1002/ejoc.200400702

Reference yield:

4-(3,5-difluoro-4-iodo-phenyl)-4'-propyl-bicyclohexyl (140918-34-9) → 4-(3,5-difluoro-4-trifluoromethanesulfinyl-phenyl)-4'-propyl-bicyclohexyl (851341-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / 1-methyl-pyrrolidin-2-one / 18 h / 120 - 150 °C

2: 28 percent / MCPBA / CH₂Cl₂ / 72 h / 20 °C

With 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane;

DOI:10.1002/ejoc.200400702

upstream raw materials:

4-(3,5-difluoro-4-trifluoromethylsulfanyl-phenyl)-4'-propyl-bicyclohexyl

2,6-difluoro-4-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)benzene

4-(3,5-difluoro-4-iodo-phenyl)-4'-propyl-bicyclohexyl